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Abstract：
UNASSIGNED: Congenital heart disease (CHD) entails structural defects in the morphogenesis of the heart or its main vessels. Analyzing exercise capacity of children and adolescents with CHD is important to improve their functional condition and quality of life, since it can allow timely intervention on poor prognostic factors associated with higher risk of morbidity and mortality.
UNASSIGNED: To describe exercise capacity in children and adolescents with CHD compared with healthy controls.
UNASSIGNED: A systematic review was carried out. Randomized clinical trials and observational studies were included assessing exercise capacity through direct and indirect methods in children and adolescents between 5 and 17 years-old. A sensitive analysis was performed including studies with CHD repaired participants. Additionally, it was sub-analyzed by age range (< and ≥ 12 years old). Two independent reviewers analyzed the studies, extracted the data, and assessed the quality of the evidence.
UNASSIGNED: 5619 articles were found and 21 were considered for the review. Eighteen articles used the direct exercise capacity measurement method by cardiopulmonary exercise test (CPET). The CHD group showed significant differences in peak oxygen consumption (VO2peak) with a value of -7.9 ml/Kg/min (95% CI: -9.9, -5.9, p = 0.00001), maximum workload (Wmax) -41.5 (95% CI: -57.9, -25.1 watts, p = 0.00001), ventilatory equivalent (VE/VCO2 ) slope 2.6 (95% CI: 0.3, 4.8), oxygen pulse (O2 pulse)-2.4 ml/beat (95% CI: -3.7, -1.1, p = 0.0003), and maximum heart rate (HRmax) -15 bpm (95% CI: -18, -12 bpm, p = 0.00001), compared with healthy controls. Adolescents (≥ 12 yrs) with CHD had a greater reduction in VO2peak (-10.0 ml/Kg/min (95% CI: -12.0, -5.3), p < 0.00001), Wmax (-45.5 watts (95% CI: -54.4, -36.7), p < 0.00001) and HRmax (-21 bpm (95% CI: -28, -14), p<0.00001).
UNASSIGNED: Suffering CHD in childhood and adolescence is associated with lower exercise capacity as shown by worse VO2peak, Wmax, VE/VCO2 slope, O2 pulse, and HRmax compared with matched healthy controls. The reduction in exercise capacity was greater in adolescents.
UNASSIGNED: www.crd.york.ac.uk/prospero/display_record.php?RecordID=208963, identifier: CRD42020208963.
UNASSIGNED: To describe exercise capacity in children and adolescents with CHD compared with healthy controls.
UNASSIGNED: A systematic review was carried out. Randomized clinical trials and observational studies were included assessing exercise capacity through direct and indirect methods in children and adolescents between 5 and 17 years-old. A sensitive analysis was performed including studies with CHD repaired participants. Additionally, it was sub-analyzed by age range (< and ≥ 12 years old). Two independent reviewers analyzed the studies, extracted the data, and assessed the quality of the evidence.
UNASSIGNED: 5619 articles were found and 21 were considered for the review. Eighteen articles used the direct exercise capacity measurement method by cardiopulmonary exercise test (CPET). The CHD group showed significant differences in peak oxygen consumption (VO2peak) with a value of -7.9 ml/Kg/min (95% CI: -9.9, -5.9, p = 0.00001), maximum workload (Wmax) -41.5 (95% CI: -57.9, -25.1 watts, p = 0.00001), ventilatory equivalent (VE/VCO2 ) slope 2.6 (95% CI: 0.3, 4.8), oxygen pulse (O2 pulse)-2.4 ml/beat (95% CI: -3.7, -1.1, p = 0.0003), and maximum heart rate (HRmax) -15 bpm (95% CI: -18, -12 bpm, p = 0.00001), compared with healthy controls. Adolescents (≥ 12 yrs) with CHD had a greater reduction in VO2peak (-10.0 ml/Kg/min (95% CI: -12.0, -5.3), p < 0.00001), Wmax (-45.5 watts (95% CI: -54.4, -36.7), p < 0.00001) and HRmax (-21 bpm (95% CI: -28, -14), p<0.00001).
UNASSIGNED: Suffering CHD in childhood and adolescence is associated with lower exercise capacity as shown by worse VO2peak, Wmax, VE/VCO2 slope, O2 pulse, and HRmax compared with matched healthy controls. The reduction in exercise capacity was greater in adolescents.
UNASSIGNED: www.crd.york.ac.uk/prospero/display_record.php?RecordID=208963, identifier: CRD42020208963.
摘要：
未经授权：先天性心脏病（CHD）在心脏或其主要血管的形态发生方面存在结构缺陷。分析CHD儿童和青少年的运动能力对改善其功能状况和生活质量具有重要意义。因为它可以及时干预与较高的发病率和死亡率相关的不良预后因素。
UNASSIGNED：描述CHD儿童和青少年与健康对照组相比的运动能力。
UNASSIGNED：进行了系统评价。随机临床试验和观察性研究包括通过直接和间接方法评估5至17岁儿童和青少年的运动能力。进行了敏感性分析，包括对CHD修复参与者的研究。此外,按年龄范围(<和≥12岁)进行亚分析.两名独立审稿人分析了这些研究，提取数据，并评估了证据的质量。
UNASSIGNED：共发现5619篇文章，其中21篇被考虑用于审查。18篇文章采用心肺运动试验（CPET）直接运动能力测量方法。CHD组显示峰值耗氧量（VO2peak）的显着差异，值为-7.9ml/Kg/min（95％CI：-9.9，-5.9，p=0.00001），最大工作负载(Wmax)-41.5(95%CI:-57.9,-25.1瓦,p=0.00001),通气当量（VE/VCO2）斜率2.6（95%CI：0.3，4.8），氧脉冲（O2脉冲）-2.4ml/beat（95％CI：-3.7，-1.1，p=0.0003），和最大心率（HRmax）-15bpm（95％CI：-18，-12bpm，p=0.00001),与健康对照相比。患有冠心病的青少年（≥12岁）的VO2peak降低更大（-10.0ml/Kg/min（95％CI：-12.0，-5.3），p<0.00001),Wmax(-45.5瓦(95%CI:-54.4,-36.7),p<0.00001）和HRmax（-21bpm（95%CI：-28，-14），p<0.00001)。
UNASSIGNED：儿童和青少年患冠心病与较低的运动能力有关，如VO2peak恶化所示，Wmax,VE/VCO2斜率,O2脉冲,和HRmax与匹配的健康对照相比。青少年的运动能力下降幅度更大。
UNASSIGNED：www.crd.约克。AC.uk/prospro/display_record.php?RecordID=208963，标识符：CRD42020208963。
UNASSIGNED：描述CHD儿童和青少年与健康对照组相比的运动能力。
UNASSIGNED：进行了系统评价。随机临床试验和观察性研究包括通过直接和间接方法评估5至17岁儿童和青少年的运动能力。进行了敏感性分析，包括对CHD修复参与者的研究。此外,按年龄范围(<和≥12岁)进行亚分析.两名独立审稿人分析了这些研究，提取数据，并评估了证据的质量。
UNASSIGNED：共发现5619篇文章，其中21篇被考虑用于审查。18篇文章采用心肺运动试验（CPET）直接运动能力测量方法。CHD组显示峰值耗氧量（VO2peak）的显着差异，值为-7.9ml/Kg/min（95％CI：-9.9，-5.9，p=0.00001），最大工作负载(Wmax)-41.5(95%CI:-57.9,-25.1瓦,p=0.00001),通气当量（VE/VCO2）斜率2.6（95%CI：0.3，4.8），氧脉冲（O2脉冲）-2.4ml/beat（95％CI：-3.7，-1.1，p=0.0003），和最大心率（HRmax）-15bpm（95％CI：-18，-12bpm，p=0.00001),与健康对照相比。患有冠心病的青少年（≥12岁）的VO2peak降低更大（-10.0ml/Kg/min（95％CI：-12.0，-5.3），p<0.00001),Wmax(-45.5瓦(95%CI:-54.4,-36.7),p<0.00001）和HRmax（-21bpm（95%CI：-28，-14），p<0.00001)。
UNASSIGNED：儿童和青少年患冠心病与较低的运动能力有关，如VO2peak恶化所示，Wmax,VE/VCO2斜率,O2脉冲,和HRmax与匹配的健康对照相比。青少年的运动能力下降幅度更大。
UNASSIGNED：www.crd.约克。AC.uk/prospro/display_record.php?RecordID=208963，标识符：CRD42020208963。
