Abstract：
Acinetobacter baumannii, a Gram-negative, glucose non-fermentative coccobacilli are responsible for causing a wide range of opportunistic nosocomial infections, thus listed as a WHO \"critical priority pathogen\", for which identification and development of new antibacterial agents are an urgent unmet medical need. The current review attempts to present an overview of various mechanisms (enzymatic and non-enzymatic), virulence factors responsible for A. baumannii resistance. Furthermore, inhibitors of A. baumannii are categorized into different classes highlighting their MDR inhibition properties. In addition, novel adjuvants that potentiate existing antibiotics, as well as natural and synthetic compounds that limit biofilm formation in A. baumannii infections are discussed.
摘要：
鲍曼不动杆菌,革兰氏阴性，葡萄糖非发酵球菌是造成广泛的机会性医院感染的原因，因此被列为世卫组织“关键优先病原体”，为此，鉴定和开发新的抗菌剂是一个迫切的未满足的医疗需求。当前的综述试图概述各种机制(酶促和非酶促)，负责鲍曼不动杆菌抗性的毒力因子。此外，鲍曼不动杆菌的抑制剂分为不同的类别，突出了它们的MDR抑制特性。此外,增强现有抗生素的新型佐剂，以及限制鲍曼不动杆菌感染中生物膜形成的天然和合成化合物。
