PDF(Pubmed)
Abstract：
Metastases to the brain from primary colorectal carcinoma are rare. Existing literature describing cranial nerve palsy from metastatic colorectal cancer is scattered. To our knowledge, we are the first to describe the combination of CN deficits V, VII, and XII as the initial presentation of colorectal malignancy. The authors present the case of a patient with no past medical history who presented with multiple cranial nerve deficits of the right trigeminal, facial, and hypoglossal nerves. MRI of the brain revealed a mass in Meckel\'s cave, which explained the involvement of the trigeminal nerve (CN V) but not the facial (CN VII) and hypoglossal (CN XII) nerves. Further workup revealed multiple cardioembolic strokes caused by nonbacterial thrombotic endocarditis (NBTE). Extensive workup for the cause of his NBTE and subsequent cerebrovascular events revealed colorectal adenocarcinoma.
摘要：
原发性结直肠癌向大脑的转移很少见。现有文献描述的颅神经麻痹来自转移性结直肠癌是零散的。据我们所知,我们是第一个描述CN赤字V组合的人，VII,和XII作为结直肠恶性肿瘤的初始表现。作者介绍了一个没有既往病史的患者，他表现为右三叉神经的多个颅神经缺陷，面部,和舌下神经.脑部核磁共振显示Meckel的洞穴有肿块,这解释了三叉神经（CNV）的受累，而不是面部（CNVII）和舌下神经（CNXII）的受累。进一步的检查显示，由非细菌性血栓性心内膜炎（NBTE）引起的多次心脏栓塞性中风。对他的NBTE和随后的脑血管事件的原因进行了广泛的检查，发现结直肠腺癌。
