Abstract：
β-Nb2ZnO6 nanoparticles were synthesized by a hydrothermal process and calcined at two temperatures, 500 °C and 700 °C, and assigned as A and B, respectively. X-ray diffraction, together with transmission electron microscopy, revealed that the β-Nb2ZnO6 nanoparticles calcined at 700 °C (B) were more crystalline than the β-Nb2ZnO6 calcined at 500 °C (A) with both types of nanoparticles having an average size of approximately 100 nm. The physiochemical, photocatalytic, and cytotoxic activities of both types of β-Nb2ZnO6 nanoparticles (A and B) were examined. Interestingly, the photodegradation of methyl orange, used as a standard for environmental pollutants, was faster in the presence of the β-Nb2ZnO6 nanoparticles calcined at 500 °C (A) than in the presence of those calcined at 700 °C (B). Moreover, the cytotoxicity was evaluated against different types of cancer cells and the results indicated that both types of β-Nb2ZnO6 nanoparticles (A and B) exhibited high cytotoxicity against MCF-7 and HCT116 cells but low cytotoxicity against HeLa cells after 24 and 48 h of treatment. Overall, both products expressed similar EC50 values on tested cell lines and high cytotoxicity after 72 h of treatment. As a photocatalyst, β-Nb2ZnO6 nanoparticles (A) could be utilized in different applications including the purification of the environment and water from specific pollutants. Further biological studies are required to determine the other potential impacts of utilizing β-Nb2ZnO6 nanoparticles in the biomedical application field.
摘要：
通过水热法合成了β-Nb2ZnO6纳米颗粒，并在两种温度下煅烧，500°C和700°C，并被分配为A和B，分别。X射线衍射,与透射电子显微镜一起，揭示了在700°C下煅烧的β-Nb2ZnO6纳米颗粒(B)比在500°C下煅烧的β-Nb2ZnO6(A)更结晶,两种类型的纳米颗粒具有约100nm的平均尺寸。物理化学，光催化,并检查了两种类型的β-Nb2ZnO6纳米颗粒（A和B）的细胞毒性活性。有趣的是,甲基橙的光降解，用作环境污染物的标准，在500°C煅烧的β-Nb2ZnO6纳米颗粒的存在下(A)比在700°C煅烧的那些纳米颗粒的存在下(B)更快。此外，对不同类型的癌细胞进行了细胞毒性评估，结果表明，两种类型的β-Nb2ZnO6纳米颗粒（A和B）对MCF-7和HCT116细胞均表现出高的细胞毒性，但对HeLa细胞的细胞毒性较低。总的来说,两种产物在试验细胞系中的EC50值相似,处理72小时后细胞毒性高.作为光催化剂,β-Nb2ZnO6纳米颗粒(A)可用于不同的应用,包括从特定污染物中净化环境和水。需要进一步的生物学研究来确定在生物医学应用领域中利用β-Nb2ZnO6纳米颗粒的其他潜在影响。
