PDF(Pubmed)
Abstract：
Mitochondria play a crucial role in cell physiology and pathophysiology. In this context, mitochondrial dynamics and, subsequently, mitochondrial ultrastructure have increasingly become hot topics in modern research, with a focus on mitochondrial fission and fusion. Thus, the dynamics of mitochondria in several diseases have been intensively investigated, especially with a view to developing new promising treatment options. However, the majority of recent studies are performed in highly energy-dependent tissues, such as cardiac, hepatic, and neuronal tissues. In contrast, publications on mitochondrial dynamics from the orthopedic or trauma fields are quite rare, even if there are common cellular mechanisms in cardiovascular and bone tissue, especially regarding bone infection. The present report summarizes the spectrum of mitochondrial alterations in the cardiovascular system and compares it to the state of knowledge in the musculoskeletal system. The present paper summarizes recent knowledge regarding mitochondrial dynamics and gives a short, but not exhaustive, overview of its regulation via fission and fusion. Furthermore, the article highlights hypoxia and its accompanying increased mitochondrial fission as a possible link between cardiac ischemia and inflammatory diseases of the bone, such as osteomyelitis. This opens new innovative perspectives not only for the understanding of cellular pathomechanisms in osteomyelitis but also for potential new treatment options.
摘要：
线粒体在细胞生理学和病理生理学中起着至关重要的作用。在这种情况下，线粒体动力学和，随后,线粒体超微结构日益成为现代研究的热点,专注于线粒体裂变和融合。因此，线粒体在几种疾病中的动力学已经被深入研究，特别是为了开发新的有希望的治疗方案。然而,最近的大多数研究是在高度能量依赖的组织中进行的，比如心脏，肝，和神经元组织。相比之下,来自骨科或创伤领域的线粒体动力学的出版物非常罕见，即使在心血管和骨组织中有共同的细胞机制，尤其是骨感染.本报告总结了心血管系统中线粒体改变的频谱，并将其与肌肉骨骼系统中的知识状态进行了比较。本文总结了有关线粒体动力学的最新知识，但并不详尽，通过裂变和聚变对其调节的概述。此外，这篇文章强调了缺氧及其伴随的线粒体裂变增加，可能是心脏缺血和骨炎性疾病之间的联系，比如骨髓炎。这不仅为了解骨髓炎的细胞病理机制，而且为潜在的新治疗选择开辟了新的创新视角。
