Abstract：
BACKGROUND: Polyphenols found abundantly in plants exhibit various anti-carcinogenic effects on tumor cells, including angiogenesis, metastasis, anti-proliferating agents, inflammation, and apoptosis. In recent years, many novel polyphenolic compounds with anticancer activity have been identified worldwide, and few of them are promising anticancer drugs to cure or inhibit cancer growth by interfering with cancer initiation, promotion, and progression.
OBJECTIVE: This mini-review aims to provide a comprehensive survey of the information about polyphenolic anticancer drugs disclosed in worldwide patents and discuss their possibility of developing as drugs used as anticancer drugs in clinical settings.
METHODS: In the present mini-review, we have revealed the anticancer properties of polyphenols presented according to their mechanisms of action. PubMed, Google Patents, and SciDirect databases were used to compile the present study.
RESULTS: In the last five years, various anticancer polyphenols were revealed in worldwide patents in the last decades, and their mode of action pointed out cytoskeletal damage, arresting cell cycle, inhibiting kinase, and tumor suppressor protein expression.
CONCLUSIONS: Many newly found polyphenols display a promising anticancer potential both in vitro and in vivo, and a few anticancer polyphenols act to inhibit the growth of various human cancer cells. Also, we have given an overview of patents filed in the last five years related to the anticancer potentials of polyphenols.
OBJECTIVE: This mini-review aims to provide a comprehensive survey of the information about polyphenolic anticancer drugs disclosed in worldwide patents and discuss their possibility of developing as drugs used as anticancer drugs in clinical settings.
METHODS: In the present mini-review, we have revealed the anticancer properties of polyphenols presented according to their mechanisms of action. PubMed, Google Patents, and SciDirect databases were used to compile the present study.
RESULTS: In the last five years, various anticancer polyphenols were revealed in worldwide patents in the last decades, and their mode of action pointed out cytoskeletal damage, arresting cell cycle, inhibiting kinase, and tumor suppressor protein expression.
CONCLUSIONS: Many newly found polyphenols display a promising anticancer potential both in vitro and in vivo, and a few anticancer polyphenols act to inhibit the growth of various human cancer cells. Also, we have given an overview of patents filed in the last five years related to the anticancer potentials of polyphenols.
摘要：
背景：在植物中大量发现的多酚对肿瘤细胞具有各种抗癌作用，包括血管生成,转移,抗增殖剂,炎症,和凋亡。近年来,许多具有抗癌活性的新型多酚化合物已在世界范围内被发现，其中很少有有希望的抗癌药物通过干扰癌症的发生来治愈或抑制癌症的生长，促销,和进步。
目的：这篇小型综述旨在对全球专利中公开的多酚抗癌药物的信息进行全面调查，并讨论其在临床环境中用作抗癌药物的药物开发的可能性。
方法：在本小型综述中，我们已经根据其作用机理揭示了多酚的抗癌特性。PubMed,谷歌专利,和SciDirect数据库用于编制本研究。
结果：在过去的五年中，在过去的几十年中，各种抗癌多酚在全球专利中被揭示，他们的作用方式指出了细胞骨架的损伤，阻止细胞周期，抑制激酶，和肿瘤抑制蛋白的表达。
结论：许多新发现的多酚在体外和体内都显示出有希望的抗癌潜力，一些抗癌多酚可以抑制各种人类癌细胞的生长。此外，我们概述了过去五年中与多酚的抗癌潜力有关的专利申请。
目的：这篇小型综述旨在对全球专利中公开的多酚抗癌药物的信息进行全面调查，并讨论其在临床环境中用作抗癌药物的药物开发的可能性。
方法：在本小型综述中，我们已经根据其作用机理揭示了多酚的抗癌特性。PubMed,谷歌专利,和SciDirect数据库用于编制本研究。
结果：在过去的五年中，在过去的几十年中，各种抗癌多酚在全球专利中被揭示，他们的作用方式指出了细胞骨架的损伤，阻止细胞周期，抑制激酶，和肿瘤抑制蛋白的表达。
结论：许多新发现的多酚在体外和体内都显示出有希望的抗癌潜力，一些抗癌多酚可以抑制各种人类癌细胞的生长。此外，我们概述了过去五年中与多酚的抗癌潜力有关的专利申请。
