PDF(Pubmed)
Abstract：
A growing body of research implicates inflammation as a potential pathway in the aetiology and pathophysiology of some mental illnesses. A systematic review was conducted to determine the association between parasitic infection and mental illnesses in humans in Africa and reviewed the state of the evidence available. The search focused on publications from Africa documenting the relationship between parasites from two parasite groups, helminths and protozoans, and four classifications of mental illness: mood affective disorders, neurotic and stress-related disorders, schizotypal disorders and unspecified mental illnesses. In the 26 reviewed papers, the prevalence of mental illness was significantly higher in people with parasitic infection compared to those without infection, i.e., 58.2% vs 41.8% (P < 0.001). An overall odds ratio found that the association of having a mental illness when testing positive for a parasitic infection was four times that of people without infection. Whilst the study showed significant associations between parasite infection and mental illness, it also highlights gaps in the present literature on the pathophysiology of mental illness in people exposed to parasite infection. This study highlighted the importance of an integrated intervention for parasitic infection and mental illness.
摘要：
越来越多的研究表明炎症是某些精神疾病的病因和病理生理学的潜在途径。进行了系统审查，以确定非洲寄生虫感染与人类精神疾病之间的关系，并审查了现有证据的状况。搜索的重点是来自非洲的出版物，这些出版物记录了来自两个寄生虫群的寄生虫之间的关系，蠕虫和原生动物,精神疾病的四种分类：情绪情感障碍，神经症和压力相关疾病，分裂型障碍和未指明的精神疾病。在26篇审阅的论文中，与没有感染的人相比，寄生虫感染的人的精神疾病患病率明显更高，即，58.2%vs41.8%(P<0.001)。总体优势比发现，寄生虫感染检测呈阳性时患有精神疾病的关联是没有感染的人的四倍。虽然研究显示寄生虫感染和精神疾病之间存在显著关联，它还强调了目前文献中关于接触寄生虫感染的人的精神疾病的病理生理学的空白。这项研究强调了对寄生虫感染和精神疾病进行综合干预的重要性。
