Eight hundred participants were randomly selected from each of the following four groups in the Sleep Heart Health Study: mild, moderate, severe or no sleep disordered breathing (n = 200 each). Overnight electrocardiograms were analyzed for QTc duration and QT variability (standard deviation of QT intervals, normalized QT interval variance and the short-term interval beat-to-beat QT variability). Cox proportional hazards penalized regression modeling was used to identify predictors of mortality.
Eight hundred of 5600 participants were randomly selected. The participants (68 ± 10 years; 56.8% male) were followed for an average of 8.2 years during which time 222 (28.4%) died. QTc, SDQT, and QTVN were associated with the presence of SDB (p = 0.002, p = 0.014, and p = 0.024, respectively). After adjusting for covariates, the presence of sleep-disordered breathing did not moderate the association between QTc length, QT variability and mortality (p > 0.05).
Sleep-disordered breathing was associated with some measures of ventricular repolarization. However, sleep-disordered breathing was not an effect modifier for the relationship between QTc and QT variability and mortality.
在睡眠心脏健康研究中,从以下四组中随机选择了八百名参与者:轻度,中度,严重或没有睡眠呼吸紊乱(每个n=200)。分析隔夜心电图的QTc持续时间和QT变异性(QT间期的标准偏差,归一化QT间期方差和短期间期搏动QT变异性)。Cox比例风险惩罚回归模型用于确定死亡率的预测因子。
随机选择了8600名参与者。参与者(68±10年;56.8%的男性)平均随访8.2年,在此期间222人(28.4%)死亡。QTc,SDQT,和QTVN与SDB的存在相关(分别为p=0.002,p=0.014和p=0.024)。在调整协变量后,睡眠呼吸紊乱的存在并没有缓和QTc长度之间的关联,QT变异性和死亡率(p>0.05)。
睡眠呼吸紊乱与心室复极的一些测量结果相关。然而,睡眠呼吸紊乱不是QTc和QT变异性与死亡率之间关系的效应调节剂.