PDF(Pubmed)
Abstract：
Serotonin-producing tumours are a subset of neuroendocrine tumours which, when active, can lead to carcinoid syndrome caused by the secretion of vasoactive substances such as serotonin, histamine, and bradykinins. In addition to the common symptoms of flushing, diarrhoea, abdominal pain, and carcinoid heart disease, carcinoid syndrome is also known to cause psychiatric symptoms of depression as well as anxiety and, very rarely, psychotic symptoms. The treatment of the neuropsychiatric manifestations of the disease is also complicated by the concurrent use of somatostatin analogues, which also affect total circulating serotonin levels, a neurotransmitter implicated in the aforementioned psychiatric disorders. In this case report, we will discuss the management of psychotic depression in a 64-year-old female patient with a metastatic carcinoid tumour and our rationale for the use of vortioxetine in her treatment.
摘要：
产生5-羟色胺的肿瘤是神经内分泌肿瘤的一个子集，当活跃时，可导致由血管活性物质如5-羟色胺的分泌引起的类癌综合征，组胺,和缓激肽.除了常见的潮红症状，腹泻,腹痛,和类癌心脏病，类癌综合征也已知会引起抑郁症和焦虑的精神症状，很少,精神病症状.该疾病的神经精神表现的治疗也因同时使用生长抑素类似物而复杂化，这也会影响总循环血清素水平，与上述精神疾病有关的神经递质。在这个案例报告中,我们将讨论一名64岁女性转移性类癌患者的精神病性抑郁症的治疗，以及我们使用沃替西汀治疗的理由。
