Abstract：
Aquagenic keratoderma is an uncommon acquired dermatosis characterized by edema and whitish-translucent papules triggered by immersion or contact with water. Cases have been described in association with certain medications, hyperhidrosis, and cystic fibrosis. The aim of this review is to evaluate the effectiveness of different treatments for aquagenic keratoderma. We reviewed the literature and analyzed treatments for aquagenic keratoderma described in case series and reports. Aquagenic keratoderma associated with hyperhidrosis can be treated effectively. Tap water iontophoresis, endoscopic thoracic sympathectomy, botulinum toxin injections, and oxybutynin are effective against refractory forms. Topical salicylic acid and aluminum salts are effective, but of little value as maintenance therapy. Oral oxybutynin 5mg/d is probably the best option for treating aquagenic keratoderma. The reported pathophysiological effects of nonsteroidal anti inflammatory drugs in this setting suggest that the use of prostaglandins might be justified. Additional studies are needed to investigate these hypotheses and resolve other questions.
摘要：
水生性角化症是一种罕见的获得性皮肤病，其特征是由浸入或接触水引起的水肿和白色半透明丘疹。已经描述了与某些药物相关的病例，多汗症,囊性纤维化.这篇综述的目的是评估不同治疗方法对水生角化病的有效性。我们回顾了文献，并分析了病例系列和报告中描述的水生角化病的治疗方法。可有效治疗与多汗症相关的水性角化病。自来水离子电渗疗法,内窥镜胸交感神经切除术,肉毒杆菌毒素注射,和奥昔布宁对难治性形式有效。局部水杨酸和铝盐是有效的，但作为维持治疗的价值不大。口服奥昔布宁5mg/d可能是治疗水生性角化病的最佳选择。报道的非甾体类抗炎药在这种情况下的病理生理作用表明，使用前列腺素可能是合理的。需要更多的研究来调查这些假设并解决其他问题。
