PDF(Pubmed)
Abstract：
Argyria is a rare disease in which chronic usage of products with a high silver content leads to deposition of silver granules in organs such as the skin, resulting in a permanent blue-gray discoloration. We present a 68-year-old woman with a 10-year history of chronic anemia of unknown etiology who was admitted for progressive generalized weakness, dyspnea, and a widespread slate-gray tint to her skin. She had previously consumed 1 tablespoon per day of colloidal silver orally for 7 years. Hematologic workup on admission showed the hemoglobin to be 2.4 g/dL with low ferritin and normal copper, zinc, and ceruloplasmin, indicating an iron-deficiency anemia. Differentiating the correct etiology of her anemia and skin discoloration was crucial since argyria can cause pseudocyanosis and microcytic anemia secondary to silver-induced copper deficiency. This case highlights the importance of asking and counseling patients about their nonprescription supplements.
摘要：
Argyria是一种罕见的疾病，其中长期使用高银含量的产品会导致银颗粒在皮肤等器官中沉积，导致永久的蓝灰色变色。我们介绍了一名68岁女性，有10年病因不明的慢性贫血病史，因进行性全身无力而入院。呼吸困难,她的皮肤上有广泛的石板灰色调。她以前每天口服1汤匙胶体银7年。入院时的血液学检查显示血红蛋白为2.4g/dL，铁蛋白低，铜正常，锌，和铜蓝蛋白,表明缺铁性贫血.区分贫血和皮肤变色的正确病因至关重要，因为银引起的铜缺乏症会导致假氰化和小红细胞性贫血。这个案例突出了询问和咨询患者非处方补充剂的重要性。
