PDF(Pubmed)
Abstract：
UNASSIGNED: Pancreatic cancer (PC) is a serious disease with high mortality. The tumor microenvironment plays a key role in the occurrence and development of PC. The purpose of this study is to analyze trends by year, country, institution, journal, reference and keyword in publications on the PC microenvironment and to predict future research hotspots.
UNASSIGNED: The Web of Science Core Collection was used to search for publications. We analyzed the contributions of various countries/regions, institutes, and authors and identified research hotspots and promising future trends using the CiteSpace and VOSviewer programs. We also summarized relevant completed clinical trials.
UNASSIGNED: A total of 2,155 papers on the PC microenvironment published between 2011 and 2021 were included in the study. The number of publications has increased every year. The average number of citations per article was 32.69. The USA had the most publications, followed by China, and a total of 50 influential articles were identified through co-citation analysis. Clustering analysis revealed two clusters of keywords: basic research and clinical application. The co-occurrence cluster analysis showed glutamine metabolism, carcinoma-associated fibroblasts, oxidative phosphorylation as the highly concerned research topics of basic research in recently. The three latest hot topics in clinical application are liposomes, endoscopic ultrasound and photodynamic therapy.
UNASSIGNED: The number of publications and research interest have generally increased, and the USA has made prominent contributions to the study of the tumor microenvironment of PC. The current research hotspots mainly focus on energy metabolism in the hypoxic tumor microenvironment, cancer associated fibroblasts in regulating the tumor microenvironment, accurate diagnosis, drug delivery and new treatments.
UNASSIGNED: The Web of Science Core Collection was used to search for publications. We analyzed the contributions of various countries/regions, institutes, and authors and identified research hotspots and promising future trends using the CiteSpace and VOSviewer programs. We also summarized relevant completed clinical trials.
UNASSIGNED: A total of 2,155 papers on the PC microenvironment published between 2011 and 2021 were included in the study. The number of publications has increased every year. The average number of citations per article was 32.69. The USA had the most publications, followed by China, and a total of 50 influential articles were identified through co-citation analysis. Clustering analysis revealed two clusters of keywords: basic research and clinical application. The co-occurrence cluster analysis showed glutamine metabolism, carcinoma-associated fibroblasts, oxidative phosphorylation as the highly concerned research topics of basic research in recently. The three latest hot topics in clinical application are liposomes, endoscopic ultrasound and photodynamic therapy.
UNASSIGNED: The number of publications and research interest have generally increased, and the USA has made prominent contributions to the study of the tumor microenvironment of PC. The current research hotspots mainly focus on energy metabolism in the hypoxic tumor microenvironment, cancer associated fibroblasts in regulating the tumor microenvironment, accurate diagnosis, drug delivery and new treatments.
摘要：
未经证实：胰腺癌（PC）是一种高死亡率的严重疾病。肿瘤微环境在PC的发生发展中起着关键作用。这项研究的目的是按年份分析趋势，国家,机构,journal,在PC微环境上的出版物中引用和关键字，并预测未来的研究热点。
UNASSIGNED：WebofScienceCoreCollection用于搜索出版物。我们分析了各个国家/地区的贡献，研究所,和作者，并使用CiteSpace和VOSviewer程序确定了研究热点和有希望的未来趋势。我们还总结了相关已完成的临床试验。
UNASSIGNED：在2011年至2021年间发表的关于PC微环境的总共2155篇论文被纳入研究。出版物的数量每年都在增加。每篇文章的平均引用次数为32.69次。美国有最多的出版物，其次是中国,通过共引分析，共确定了50篇有影响力的文章。聚类分析揭示了两个关键词：基础研究和临床应用。共生聚类分析显示谷氨酰胺代谢，癌相关成纤维细胞，氧化磷酸化作为近年来基础研究高度关注的研究课题。临床应用的三个最新热点是脂质体,超声内镜和光动力治疗。
UNASSIGNED：出版物数量和研究兴趣普遍增加，美国对PC的肿瘤微环境研究做出了突出贡献。目前的研究热点主要集中在缺氧肿瘤微环境中的能量代谢,癌症相关的成纤维细胞在调节肿瘤微环境中，准确诊断,药物输送和新的治疗方法。
UNASSIGNED：WebofScienceCoreCollection用于搜索出版物。我们分析了各个国家/地区的贡献，研究所,和作者，并使用CiteSpace和VOSviewer程序确定了研究热点和有希望的未来趋势。我们还总结了相关已完成的临床试验。
UNASSIGNED：在2011年至2021年间发表的关于PC微环境的总共2155篇论文被纳入研究。出版物的数量每年都在增加。每篇文章的平均引用次数为32.69次。美国有最多的出版物，其次是中国,通过共引分析，共确定了50篇有影响力的文章。聚类分析揭示了两个关键词：基础研究和临床应用。共生聚类分析显示谷氨酰胺代谢，癌相关成纤维细胞，氧化磷酸化作为近年来基础研究高度关注的研究课题。临床应用的三个最新热点是脂质体,超声内镜和光动力治疗。
UNASSIGNED：出版物数量和研究兴趣普遍增加，美国对PC的肿瘤微环境研究做出了突出贡献。目前的研究热点主要集中在缺氧肿瘤微环境中的能量代谢,癌症相关的成纤维细胞在调节肿瘤微环境中，准确诊断,药物输送和新的治疗方法。
