Abstract：
Uremic calciphylaxis is a rare disease that affects patients with chronic end-stage renal disease. It is a pathology of the microvessels of the dermis and hypodermis which are calcified and whose thrombosis leads to skin necrosis. Calciphylaxis lesions can be distal and axial. They lead to pain, infection and are associated with denutrition and in high mortality rate (40-80% at 1 year). This general review describes the clinical and para-clinical presentations of calciphylaxis. It summarizes the current knowledge on its pathogenesis and the therapeutical options that can be proposed to improve the management and attempt to reduce the mortality of patients with uremic calciphylaxis.
摘要：
尿毒症钙化是一种罕见的疾病，影响慢性终末期肾病患者。它是钙化的真皮和皮下组织的微血管的病理学，其血栓形成导致皮肤坏死。钙化敏感病变可以是远端和轴向的。它们会导致疼痛，感染，与营养不良相关，死亡率高(1年为40-80%)。本一般综述描述了钙化的临床和副临床表现。它总结了有关其发病机理的最新知识以及可以提出的治疗选择，以改善管理并尝试降低尿毒症钙化预防患者的死亡率。
