This prospective randomized crossover study was conducted between January 2015 and January 2017. We included 20 adults aged 20-65 years who fulfilled the diagnosis criteria for CID. Participants underwent 2 overnight polysomnography studies with an interval of at least 7 days. They were awakened during either rapid eye movement (REM) sleep or stage N1/N2 sleep alternatively. We compared measurements of static postural stability, vigilance scores, and neuropsychological tests between REM sleep and stage N1/N2 sleep awakening.
Polysomnography parameters between the 2 nights were comparable. Participants who were awakened from REM sleep had worse static postural stability than those with stage N1/N2 sleep awakening. Compared with stage N1/N2 sleep awakening, larger mean sway areas of center of pressure (P = .0413) and longer center-of-pressure mean distances (P = .0139) were found in REM sleep awakening. There were no statistically significant differences in vigilance scores or neuropsychological tests between the 2 nights.
REM sleep awakening was associated with worse static postural stability than was stage N1/N2 sleep awakening. No statistically significant differences were found in waking performance in alertness or in neuropsychological tests between stage N1/N2 and REM sleep awakening.
Yeh W-C, Chuang Y-C, Yen C-W, et al. Static postural stability and neuropsychological performance after awakening from REM and NREM sleep in patients with chronic insomnia: a randomized, crossover, overnight polysomnography study. J Clin Sleep Med. 2022;18(8):1983-1992.
这项前瞻性随机交叉研究于2015年1月至2017年1月进行。我们纳入了20名年龄在20-65岁之间的成年人,他们符合CID的诊断标准。参与者进行了2次过夜多导睡眠图研究,间隔至少7天。他们在快速眼动(REM)睡眠或N1/N2阶段睡眠中被唤醒。我们比较了静态姿势稳定性的测量结果,警惕分数,REM睡眠和N1/N2睡眠觉醒之间的神经心理学测试。
两晚之间的多导睡眠图参数具有可比性。与N1/N2睡眠唤醒阶段的参与者相比,从REM睡眠中醒来的参与者的静态姿势稳定性较差。与N1/N2睡眠觉醒阶段相比,在REM睡眠觉醒中发现了较大的压力中心平均摇摆面积(P=.0413)和较长的压力中心平均距离(P=.0139)。2晚之间的警惕性评分或神经心理学测试没有统计学上的显着差异。
与N1/N2阶段睡眠觉醒相比,REM睡眠觉醒与静态姿势稳定性较差相关。在N1/N2阶段和REM睡眠觉醒之间,警觉性清醒表现或神经心理学测试中没有发现统计学上的显着差异。
是W-C,ChuangY-C,日元C-W,etal.慢性失眠患者从REM和NREM睡眠唤醒后的静态姿势稳定性和神经心理学表现:一项随机研究,交叉,过夜多导睡眠图研究。JClinSleepMed.2022年;18(8):1983-1992年。