PDF(Pubmed)
Abstract：
Chronic insomnia disorder (CID) is a common sleep disorder, with a prevalence ranging from 6%-10% worldwide. Individuals with CID experience more fragmented sleep than healthy control patients do. They awaken frequently during the night and have a higher risk of injury from falling. Awakening from different sleep stages may have different effects on postural stability and waking performance. However, limited research has been conducted on this topic.
This prospective randomized crossover study was conducted between January 2015 and January 2017. We included 20 adults aged 20-65 years who fulfilled the diagnosis criteria for CID. Participants underwent 2 overnight polysomnography studies with an interval of at least 7 days. They were awakened during either rapid eye movement (REM) sleep or stage N1/N2 sleep alternatively. We compared measurements of static postural stability, vigilance scores, and neuropsychological tests between REM sleep and stage N1/N2 sleep awakening.
Polysomnography parameters between the 2 nights were comparable. Participants who were awakened from REM sleep had worse static postural stability than those with stage N1/N2 sleep awakening. Compared with stage N1/N2 sleep awakening, larger mean sway areas of center of pressure (P = .0413) and longer center-of-pressure mean distances (P = .0139) were found in REM sleep awakening. There were no statistically significant differences in vigilance scores or neuropsychological tests between the 2 nights.
REM sleep awakening was associated with worse static postural stability than was stage N1/N2 sleep awakening. No statistically significant differences were found in waking performance in alertness or in neuropsychological tests between stage N1/N2 and REM sleep awakening.
Yeh W-C, Chuang Y-C, Yen C-W, et al. Static postural stability and neuropsychological performance after awakening from REM and NREM sleep in patients with chronic insomnia: a randomized, crossover, overnight polysomnography study. J Clin Sleep Med. 2022;18(8):1983-1992.
This prospective randomized crossover study was conducted between January 2015 and January 2017. We included 20 adults aged 20-65 years who fulfilled the diagnosis criteria for CID. Participants underwent 2 overnight polysomnography studies with an interval of at least 7 days. They were awakened during either rapid eye movement (REM) sleep or stage N1/N2 sleep alternatively. We compared measurements of static postural stability, vigilance scores, and neuropsychological tests between REM sleep and stage N1/N2 sleep awakening.
Polysomnography parameters between the 2 nights were comparable. Participants who were awakened from REM sleep had worse static postural stability than those with stage N1/N2 sleep awakening. Compared with stage N1/N2 sleep awakening, larger mean sway areas of center of pressure (P = .0413) and longer center-of-pressure mean distances (P = .0139) were found in REM sleep awakening. There were no statistically significant differences in vigilance scores or neuropsychological tests between the 2 nights.
REM sleep awakening was associated with worse static postural stability than was stage N1/N2 sleep awakening. No statistically significant differences were found in waking performance in alertness or in neuropsychological tests between stage N1/N2 and REM sleep awakening.
Yeh W-C, Chuang Y-C, Yen C-W, et al. Static postural stability and neuropsychological performance after awakening from REM and NREM sleep in patients with chronic insomnia: a randomized, crossover, overnight polysomnography study. J Clin Sleep Med. 2022;18(8):1983-1992.
摘要：
慢性失眠障碍(CID)是一种常见的睡眠障碍,全球患病率为6%-10%。患有CID的个体比健康对照患者经历更多的零散睡眠。他们在夜间经常醒来，跌倒受伤的风险更高。不同睡眠阶段的觉醒可能对姿势稳定性和清醒表现有不同的影响。然而,对这一主题进行了有限的研究。
这项前瞻性随机交叉研究于2015年1月至2017年1月进行。我们纳入了20名年龄在20-65岁之间的成年人，他们符合CID的诊断标准。参与者进行了2次过夜多导睡眠图研究，间隔至少7天。他们在快速眼动（REM）睡眠或N1/N2阶段睡眠中被唤醒。我们比较了静态姿势稳定性的测量结果，警惕分数，REM睡眠和N1/N2睡眠觉醒之间的神经心理学测试。
两晚之间的多导睡眠图参数具有可比性。与N1/N2睡眠唤醒阶段的参与者相比，从REM睡眠中醒来的参与者的静态姿势稳定性较差。与N1/N2睡眠觉醒阶段相比，在REM睡眠觉醒中发现了较大的压力中心平均摇摆面积（P=.0413）和较长的压力中心平均距离（P=.0139）。2晚之间的警惕性评分或神经心理学测试没有统计学上的显着差异。
与N1/N2阶段睡眠觉醒相比，REM睡眠觉醒与静态姿势稳定性较差相关。在N1/N2阶段和REM睡眠觉醒之间，警觉性清醒表现或神经心理学测试中没有发现统计学上的显着差异。
是W-C,ChuangY-C,日元C-W,etal.慢性失眠患者从REM和NREM睡眠唤醒后的静态姿势稳定性和神经心理学表现：一项随机研究，交叉，过夜多导睡眠图研究。JClinSleepMed.2022年；18（8）：1983-1992年。
这项前瞻性随机交叉研究于2015年1月至2017年1月进行。我们纳入了20名年龄在20-65岁之间的成年人，他们符合CID的诊断标准。参与者进行了2次过夜多导睡眠图研究，间隔至少7天。他们在快速眼动（REM）睡眠或N1/N2阶段睡眠中被唤醒。我们比较了静态姿势稳定性的测量结果，警惕分数，REM睡眠和N1/N2睡眠觉醒之间的神经心理学测试。
两晚之间的多导睡眠图参数具有可比性。与N1/N2睡眠唤醒阶段的参与者相比，从REM睡眠中醒来的参与者的静态姿势稳定性较差。与N1/N2睡眠觉醒阶段相比，在REM睡眠觉醒中发现了较大的压力中心平均摇摆面积（P=.0413）和较长的压力中心平均距离（P=.0139）。2晚之间的警惕性评分或神经心理学测试没有统计学上的显着差异。
与N1/N2阶段睡眠觉醒相比，REM睡眠觉醒与静态姿势稳定性较差相关。在N1/N2阶段和REM睡眠觉醒之间，警觉性清醒表现或神经心理学测试中没有发现统计学上的显着差异。
是W-C,ChuangY-C,日元C-W,etal.慢性失眠患者从REM和NREM睡眠唤醒后的静态姿势稳定性和神经心理学表现：一项随机研究，交叉，过夜多导睡眠图研究。JClinSleepMed.2022年；18（8）：1983-1992年。
