Abstract：
Magnesium (Mg) alloys as implant materials with excellent biodegradation ability have promising clinical applications for tissue repair and restoration. Although the corrosion processes of Mg alloys in biophysiological media are closely related with their biodegradation ability, only limited methods have been developed for characterization of their corrosion processes, including electrochemical analysis, weight loss measurement, and hydrogen evolution analysis. Moreover, these methods suffer from drawbacks of poor spatiotemporal resolution, static observation, and tedious operation. To tackle these challenges, we herein developed a fluorescent probe PSPA for in situ 3D monitoring of the dynamic corrosion processes of Mg alloys on the basis of its selective turn-on detection ability toward magnesium hydroxide [Mg(OH)2], which is the main corrosion product of Mg alloys in biophysiological media. As far as we know, this is the first example of a fluorescent probe for the monitoring of corrosion processes of Mg alloys in biophysiological media. We believe this fluorescence analysis method with easy operation and high spatiotemporal resolution advantages will contribute greatly to the clinical applications of Mg alloy implants.
摘要：
镁（Mg）合金作为具有优异生物降解能力的植入材料，在组织修复和修复中具有广阔的临床应用前景。尽管镁合金在生物卫生学介质中的腐蚀过程与其生物降解能力密切相关,仅开发了有限的方法来表征其腐蚀过程，包括电化学分析，重量损失测量，和析氢分析。此外，这些方法存在时空分辨率差的缺点，静态观察，和乏味的操作。为了应对这些挑战，我们在此开发了一种荧光探针PSPA，用于原位3D监测镁合金的动态腐蚀过程，基于其对氢氧化镁[Mg（OH）2]的选择性开启检测能力，是镁合金在生物卫生学介质中的主要腐蚀产物。据我们所知,这是用于监测镁合金在生物生理学介质中的腐蚀过程的荧光探针的第一个例子。我们相信这种荧光分析方法具有操作简便、时空分辨率高等优点，将极大地促进镁合金植入物的临床应用。
