PDF(Pubmed)
Abstract：
UNASSIGNED: The present research aimed to study the relationship between body mass index (BMI), sex hormones, leptin, and irisin in children and adolescents with different body types.
UNASSIGNED: In this study, a stratified cluster random sampling method was used to select students aged 8-15 years from two 9-year schools as the research subjects. Based on a case-control study, 183 overweight/obese students were selected. After using sex and age matching to create a matched sample of normal-weighted students, a total of 366 students, including 214 boys (58.5%) and 152 girls (41.5%) were included. We measured their height and weight and calculated their body mass index BMI. Afterward, their concentrations of leptin, irisin, oestradiol (E2), and testosterone (T) in the serum were detected.
UNASSIGNED: There were significant differences in T, E2, leptin, and irisin between normal-weighted boys and girls (p < 0.05). There were statistically significant differences in T, E2, and irisin between overweight/obese boys and girls (p < 0.05). Overweight/obese students had higher concentrations of irisin and leptin than normal-weight students (p < 0.05). The direct effect of BMI on irisin was not statistically significant in either normal or overweight/obese students, but their indirect effects via leptin were statistically significant (for normal-weight boys and girls, standardized indirect effect coefficient: 0.29 and 0.38, respectively; for overweight/obese boys and girls, standardized indirect effect coefficient: 0.36 and 0.34, respectively). There was a negative pathway of E2 → leptin → irisin in normal-weight boys (standardized indirect effect coefficient: -0.24) and a negative pathway of T → leptin → irisin in overweight/obese boys (standardized indirect effect coefficient: -0.27).
UNASSIGNED: The indirect effects of BMI on irisin via leptin exist in children and adolescents of different body types. E2 was negatively correlated with leptin in normal-weight boys, whereas T was negatively correlated with leptin in overweight/obese boys.
UNASSIGNED: In this study, a stratified cluster random sampling method was used to select students aged 8-15 years from two 9-year schools as the research subjects. Based on a case-control study, 183 overweight/obese students were selected. After using sex and age matching to create a matched sample of normal-weighted students, a total of 366 students, including 214 boys (58.5%) and 152 girls (41.5%) were included. We measured their height and weight and calculated their body mass index BMI. Afterward, their concentrations of leptin, irisin, oestradiol (E2), and testosterone (T) in the serum were detected.
UNASSIGNED: There were significant differences in T, E2, leptin, and irisin between normal-weighted boys and girls (p < 0.05). There were statistically significant differences in T, E2, and irisin between overweight/obese boys and girls (p < 0.05). Overweight/obese students had higher concentrations of irisin and leptin than normal-weight students (p < 0.05). The direct effect of BMI on irisin was not statistically significant in either normal or overweight/obese students, but their indirect effects via leptin were statistically significant (for normal-weight boys and girls, standardized indirect effect coefficient: 0.29 and 0.38, respectively; for overweight/obese boys and girls, standardized indirect effect coefficient: 0.36 and 0.34, respectively). There was a negative pathway of E2 → leptin → irisin in normal-weight boys (standardized indirect effect coefficient: -0.24) and a negative pathway of T → leptin → irisin in overweight/obese boys (standardized indirect effect coefficient: -0.27).
UNASSIGNED: The indirect effects of BMI on irisin via leptin exist in children and adolescents of different body types. E2 was negatively correlated with leptin in normal-weight boys, whereas T was negatively correlated with leptin in overweight/obese boys.
摘要：
未经评估：本研究旨在研究体重指数（BMI）之间的关系，性激素,瘦素,和irisin在不同体型的儿童和青少年中。
未经批准：在这项研究中，采用分层整群随机抽样方法,从两所9年制学校中选取8~15岁的学生作为研究对象.基于一项病例对照研究，选择了183名超重/肥胖学生。在使用性别和年龄匹配创建匹配的正常加权学生样本后，共计366名学生,包括214名男孩(58.5%)和152名女孩(41.5%)。我们测量了他们的身高和体重，并计算了他们的体重指数BMI。之后,它们的瘦素浓度，irisin,雌二醇（E2），检测血清中的睾酮(T)。
未经评估：T，E2,瘦素,正常体重男孩和女孩之间的irisin（p<0.05）。T差异有统计学意义,超重/肥胖男孩和女孩之间的E2和irisin（p<0.05）。超重/肥胖学生的irisin和瘦素浓度高于正常体重学生（p<0.05）。在正常或超重/肥胖学生中，BMI对irisin的直接影响均无统计学意义，但是它们通过瘦素的间接作用具有统计学意义（对于体重正常的男孩和女孩，标准化间接影响系数：分别为0.29和0.38；对于超重/肥胖的男孩和女孩，标准化间接影响系数：分别为0.36和0.34)。正常体重男孩存在E2→瘦素→irisin的负途径（标准化间接效应系数：-0.24），超重/肥胖男孩存在T→瘦素→irisin的负途径（标准化间接效应系数：-0.27）。
UNASSIGNED：BMI通过瘦素对irisin的间接影响存在于不同体型的儿童和青少年中。在正常体重男孩中，E2与瘦素呈负相关。而在超重/肥胖男孩中，T与瘦素呈负相关。
未经批准：在这项研究中，采用分层整群随机抽样方法,从两所9年制学校中选取8~15岁的学生作为研究对象.基于一项病例对照研究，选择了183名超重/肥胖学生。在使用性别和年龄匹配创建匹配的正常加权学生样本后，共计366名学生,包括214名男孩(58.5%)和152名女孩(41.5%)。我们测量了他们的身高和体重，并计算了他们的体重指数BMI。之后,它们的瘦素浓度，irisin,雌二醇（E2），检测血清中的睾酮(T)。
未经评估：T，E2,瘦素,正常体重男孩和女孩之间的irisin（p<0.05）。T差异有统计学意义,超重/肥胖男孩和女孩之间的E2和irisin（p<0.05）。超重/肥胖学生的irisin和瘦素浓度高于正常体重学生（p<0.05）。在正常或超重/肥胖学生中，BMI对irisin的直接影响均无统计学意义，但是它们通过瘦素的间接作用具有统计学意义（对于体重正常的男孩和女孩，标准化间接影响系数：分别为0.29和0.38；对于超重/肥胖的男孩和女孩，标准化间接影响系数：分别为0.36和0.34)。正常体重男孩存在E2→瘦素→irisin的负途径（标准化间接效应系数：-0.24），超重/肥胖男孩存在T→瘦素→irisin的负途径（标准化间接效应系数：-0.27）。
UNASSIGNED：BMI通过瘦素对irisin的间接影响存在于不同体型的儿童和青少年中。在正常体重男孩中，E2与瘦素呈负相关。而在超重/肥胖男孩中，T与瘦素呈负相关。
