PDF(Pubmed)
Abstract：
UNASSIGNED: Initiation of anticoagulation therapy in ischemic stroke patients is contingent on a clinical diagnosis of atrial fibrillation (AF). Results from previous studies suggest thromboembolic risk may predate clinical manifestations of AF. Early identification of this cohort of patients may allow early initiation of anticoagulation and reduce the risk of secondary stroke.
UNASSIGNED: This study aims to produce a substrate-based predictive model using cardiac magnetic resonance imaging (CMR) and baseline noninvasive electrocardiographic investigations to improve the identification of patients at risk of future thromboembolism.
UNASSIGNED: CARM-AF is a prospective, multicenter, observational cohort study. Ninety-two patients will be recruited following an embolic stroke of unknown source (ESUS) and undergo atrial CMR followed by insertion of an implantable loop recorder (ILR) as per routine clinical care within 3 months of index stroke. Remote ILR follow-up will be used to allocate patients to a study or control group determined by the presence or absence of AF as defined by ILR monitoring.
UNASSIGNED: Baseline data collection, noninvasive electrocardiographic data analysis, and imaging postprocessing will be performed at the time of enrollment. Primary analysis will be performed following 12 months of continuous ILR monitoring, with interim and delayed analyses performed at 6 months and 2 and 3 years, respectively.
UNASSIGNED: The CARM-AF Study will use atrial structural and electrocardiographic metrics to identify patients with AF, or at high risk of developing AF, who may benefit from early initiation of anticoagulation.
UNASSIGNED: This study aims to produce a substrate-based predictive model using cardiac magnetic resonance imaging (CMR) and baseline noninvasive electrocardiographic investigations to improve the identification of patients at risk of future thromboembolism.
UNASSIGNED: CARM-AF is a prospective, multicenter, observational cohort study. Ninety-two patients will be recruited following an embolic stroke of unknown source (ESUS) and undergo atrial CMR followed by insertion of an implantable loop recorder (ILR) as per routine clinical care within 3 months of index stroke. Remote ILR follow-up will be used to allocate patients to a study or control group determined by the presence or absence of AF as defined by ILR monitoring.
UNASSIGNED: Baseline data collection, noninvasive electrocardiographic data analysis, and imaging postprocessing will be performed at the time of enrollment. Primary analysis will be performed following 12 months of continuous ILR monitoring, with interim and delayed analyses performed at 6 months and 2 and 3 years, respectively.
UNASSIGNED: The CARM-AF Study will use atrial structural and electrocardiographic metrics to identify patients with AF, or at high risk of developing AF, who may benefit from early initiation of anticoagulation.
摘要：
未经证实：缺血性卒中患者抗凝治疗的启动取决于房颤(AF)的临床诊断。先前研究的结果表明，血栓栓塞风险可能早于房颤的临床表现。早期识别该队列患者可能允许早期开始抗凝治疗并降低继发性中风的风险。
UNASSIGNED：本研究旨在使用心脏磁共振成像（CMR）和基线无创心电图检查来建立基于底物的预测模型，以提高对未来血栓栓塞风险患者的识别。
未经批准：CARM-AF是一个潜在的，多中心，观察性队列研究。在未知来源的栓塞性中风（ESUS）后，将招募92名患者，并接受心房CMR，然后在索引中风后3个月内按照常规临床护理插入植入式环路记录仪（ILR）。远程ILR随访将用于将患者分配到根据ILR监测定义的AF的存在或不存在确定的研究组或对照组。
未经评估：基线数据收集，无创心电图数据分析，和成像后处理将在登记时进行。主要分析将在12个月的连续ILR监测后进行，在6个月、2年和3年进行中期和延迟分析，分别。
未经评估：CARM-AF研究将使用心房结构和心电图指标来识别房颤患者，或发展为房颤的高风险，他们可能会从早期开始抗凝治疗中受益。
UNASSIGNED：本研究旨在使用心脏磁共振成像（CMR）和基线无创心电图检查来建立基于底物的预测模型，以提高对未来血栓栓塞风险患者的识别。
未经批准：CARM-AF是一个潜在的，多中心，观察性队列研究。在未知来源的栓塞性中风（ESUS）后，将招募92名患者，并接受心房CMR，然后在索引中风后3个月内按照常规临床护理插入植入式环路记录仪（ILR）。远程ILR随访将用于将患者分配到根据ILR监测定义的AF的存在或不存在确定的研究组或对照组。
未经评估：基线数据收集，无创心电图数据分析，和成像后处理将在登记时进行。主要分析将在12个月的连续ILR监测后进行，在6个月、2年和3年进行中期和延迟分析，分别。
未经评估：CARM-AF研究将使用心房结构和心电图指标来识别房颤患者，或发展为房颤的高风险，他们可能会从早期开始抗凝治疗中受益。
