PDF(Pubmed)
Abstract：
Antipsychotic treatment has been documented as the mainstay for the management of schizophrenia. Evidence in literature has suggested that the management of negative symptoms of schizophrenia continues to be a treatment challenge. Therefore, residual negative symptoms can become more pervasive and visible after the treatment of positive symptoms, leading to an impaired marked deficit in the vital daily functions of patients. We present a case series of three patients with a past psychiatric history of schizophrenia who presented to the psychiatric emergency with acute symptoms of schizophrenia. Following antipsychotic treatment, all these patients showed improvement of positive symptoms, however, profound negative symptoms of schizophrenia became visible. The negative symptoms include anhedonia, amotivation, alogia, affective flattening, and passive social withdrawal. We added bupropion to manage the negative symptoms, and all three patients achieved a good treatment response. This case series suggests that the anti-depressive effects of bupropion might be a valuable treatment option in the treatment of negative symptoms of schizophrenia.
摘要：
抗精神病药物治疗已被证明是精神分裂症治疗的主要手段。文献中的证据表明，精神分裂症阴性症状的管理仍然是治疗挑战。因此,残留的阴性症状在阳性症状治疗后变得更加普遍和可见，导致患者重要的日常功能受损。我们介绍了一个病例系列，其中三名具有精神分裂症既往精神病史的患者，这些患者因精神分裂症的急性症状而出现精神病紧急情况。抗精神病药物治疗后,所有这些患者都表现出阳性症状的改善，然而,精神分裂症的严重负面症状变得明显。阴性症状包括快感缺失，动机，alogia,情感扁平化，被动的社会退出。我们添加了安非他酮来控制阴性症状，3名患者均取得了良好的治疗反应。该病例系列表明，安非他酮的抗抑郁作用可能是治疗精神分裂症阴性症状的有价值的治疗选择。
