Abstract：
Female pattern hair loss (FPHL), a type of hair disease common in pre- and postmenopausal women, is characterized by thinning of hair to O-type, mainly at the crown. Although a mouse model of this disease has recently been established, its details are still unknown, and thus, warrants further analysis. In this study, 3 week-old and 7- to 8 week-old C57BL/6 female mice were divided into two groups: one group underwent ovariectomy (OVX), while the other underwent sham surgery. In the 3 week-old mice, the dorsal skin was collected at seven weeks of age, while in the 7- to 8 week-old mice, it was collected at 12 and 24 weeks of age. In the former group, both the pore size of the hair follicles (HFs) and diameter of the hair shaft of telogen HFs decreased upon OVX; while in the latter group, these factors increased significantly. Notably, the thickness of the dermis and subcutis increased significantly in the OVX group. It needs to be further elucidated whether OVX mouse could serve as an ideal mouse model for FPHL, but our results upon evaluation of skin thickness indicate that it could be used to establish a novel treatment for non-hair-related diseases, such as post-menopause-related skin condition.
摘要：
女性模式脱发（FPHL），一种在绝经前和绝经后妇女中常见的头发疾病，其特征是头发稀疏成O型，主要是在皇冠上。尽管最近已经建立了这种疾病的小鼠模型，它的细节仍然未知，因此，值得进一步分析。在这项研究中,将3周龄和7至8周龄的C57BL/6雌性小鼠分为两组：一组进行卵巢切除术（OVX），而另一个接受了假手术。在3周大的老鼠中，背部皮肤是在7周龄时收集的，在7到8周大的老鼠身上，它是在12周龄和24周龄时收集的。在前一组中，OVX后，毛囊（HFs）的孔径和毛干的直径均减小；而在后一组中，这些因素显著增加。值得注意的是,OVX组真皮和皮下组织厚度明显增加。需要进一步阐明OVX小鼠是否可以作为FPHL的理想小鼠模型，但是我们对皮肤厚度的评估结果表明，它可以用来建立一种治疗非毛发相关疾病的新方法，如绝经后相关的皮肤状况。
