Abstract：
This review of aspirin-exacerbated respiratory disease (AERD) describes the clinical characteristics and pathophysiology of disease, highlighting its similarities and unique differences in comparison to classic IgE mediated hypersensitivity as well as AERD as a chronic disease. There is a specific focus on the comparison of mediator production over time and the use of desensitization in each diagnosis that serves to aid the clinician in differentiating aspirin reactions in AERD from those related to true immediate hypersensitivity.
摘要：
本文综述了阿司匹林加重的呼吸系统疾病（AERD）的临床特征和病理生理学。强调其与经典IgE介导的超敏反应以及作为慢性疾病的AERD相比的相似性和独特差异。特别关注介质随时间产生的比较以及在每种诊断中脱敏的使用，以帮助临床医生区分AERD中的阿司匹林反应与真正的即时超敏反应。
