Abstract：
Bacterial resistance caused by antibiotic therapy is a serious problem. Therefore, there is an urgent need to find alternative methods to overcome bacterial resistance. Herein, we synthesized a new type of iridium oxide (IrOx) as an alternative to antibiotics. Iridium oxide not only has good catalytic properties, but also has photothermal properties, and then realizes the \"one body and two wings\" strategy to enhance the antibacterial effect. Research results show that near-infrared light can enhance the peroxidase catalytic activity of IrOx and generate highly toxic hydroxyl radicals (·OH) by catalyzing hydrogen peroxide (H2O2). Hydroxyl radicals have a high redox potential, which can overcome the drug resistance of gram-positive and negative bacteria. Importantly, IrOx has no obvious cellular and in vivo toxicity. Accordingly, the novel photothermal nanozyme is expected to be applied to bacterial infectious diseases, such as wound healing, sepsis, and implant-related infections.
摘要：
抗生素治疗引起的细菌耐药性是一个严重的问题。因此,迫切需要找到克服细菌耐药性的替代方法。在这里，我们合成了一种新型的氧化铱（IrOx）作为抗生素的替代品。氧化铱不仅具有良好的催化性能,而且还具有光热特性，然后实现“一体两翼”策略以增强抗菌效果。研究结果表明，近红外光可以增强IrOx的过氧化物酶催化活性，并通过催化过氧化氢（H2O2）产生高毒性的羟基自由基（·OH）。羟基自由基具有高氧化还原电位，能克服革兰阳性菌和阴性菌的耐药性。重要的是,IrOx无明显的细胞和体内毒性。因此，新型光热纳米酶有望应用于细菌感染性疾病，比如伤口愈合，脓毒症,和植入物相关的感染。
