PDF(Pubmed)
Abstract：
BACKGROUND: Specific medical conditions are more prevalent in Down syndrome (DS) compared to the general population. Medical heterogeneity has also been hypothesized to contribute to variability in outcomes in DS.
OBJECTIVE: This project aimed to examine the association between medical conditions (i.e., gastrointestinal issues, hearing loss, vision problems, and congenital heart defects) and cognition, language, and behavior in children and adolescents with DS.
METHODS: Participants were 73 children and adolescents with DS, ages 6-17 years (M = 12.67, SD = 3.16). Caregivers reported on participants\' medical conditions, social behaviors, maladaptive behaviors, and executive function. Child cognitive abilities were also assessed.
RESULTS: Of the 73 participants, 34.2% had gastrointestinal issues, 12.3% had uncorrected hearing loss, 26.0% had uncorrected vision problems, and 31.5% had congenital heart defects. Participants with gastrointestinal issues had significantly more challenges with social behaviors, maladaptive behaviors, and executive function compared to those without gastrointestinal issues.
CONCLUSIONS: The associations identified between gastrointestinal issues and caregiver-reported behavioral characteristics in youth with DS contributes to our understanding of the interrelation between co-occurring medical conditions and child outcomes and has implications for approaches to care for individuals with DS.
OBJECTIVE: This project aimed to examine the association between medical conditions (i.e., gastrointestinal issues, hearing loss, vision problems, and congenital heart defects) and cognition, language, and behavior in children and adolescents with DS.
METHODS: Participants were 73 children and adolescents with DS, ages 6-17 years (M = 12.67, SD = 3.16). Caregivers reported on participants\' medical conditions, social behaviors, maladaptive behaviors, and executive function. Child cognitive abilities were also assessed.
RESULTS: Of the 73 participants, 34.2% had gastrointestinal issues, 12.3% had uncorrected hearing loss, 26.0% had uncorrected vision problems, and 31.5% had congenital heart defects. Participants with gastrointestinal issues had significantly more challenges with social behaviors, maladaptive behaviors, and executive function compared to those without gastrointestinal issues.
CONCLUSIONS: The associations identified between gastrointestinal issues and caregiver-reported behavioral characteristics in youth with DS contributes to our understanding of the interrelation between co-occurring medical conditions and child outcomes and has implications for approaches to care for individuals with DS.
摘要：
背景：与普通人群相比，唐氏综合症（DS）中的特定医学状况更为普遍。医学异质性也被认为有助于DS结果的变异性。
目的：该项目旨在检查医疗条件之间的关联(即，肠胃问题,听力损失,视力问题,和先天性心脏缺陷)和认知，语言,儿童和青少年DS的行为。
方法：参与者为73名患有DS的儿童和青少年，年龄6-17岁（M=12.67，SD=3.16）。护理人员报告参与者的医疗状况，社会行为,适应不良的行为，和执行功能。还评估了儿童的认知能力。
结果：在73名参与者中，34.2%有胃肠道问题，12.3%有未纠正的听力损失，26.0%有未矫正视力问题，31.5%有先天性心脏缺陷。有胃肠道问题的参与者在社交行为方面有更多的挑战，适应不良的行为，与没有胃肠道问题的人相比，执行功能。
结论：在青少年DS患者中，胃肠道问题与护理人员报告的行为特征之间的关联有助于我们理解同时发生的医疗状况与儿童结局之间的相互关系，并对DS患者的护理方法具有启示意义。
目的：该项目旨在检查医疗条件之间的关联(即，肠胃问题,听力损失,视力问题,和先天性心脏缺陷)和认知，语言,儿童和青少年DS的行为。
方法：参与者为73名患有DS的儿童和青少年，年龄6-17岁（M=12.67，SD=3.16）。护理人员报告参与者的医疗状况，社会行为,适应不良的行为，和执行功能。还评估了儿童的认知能力。
结果：在73名参与者中，34.2%有胃肠道问题，12.3%有未纠正的听力损失，26.0%有未矫正视力问题，31.5%有先天性心脏缺陷。有胃肠道问题的参与者在社交行为方面有更多的挑战，适应不良的行为，与没有胃肠道问题的人相比，执行功能。
结论：在青少年DS患者中，胃肠道问题与护理人员报告的行为特征之间的关联有助于我们理解同时发生的医疗状况与儿童结局之间的相互关系，并对DS患者的护理方法具有启示意义。
