Abstract：
Due to the high prevalence of breast cancer in the female, a metastasis from primary breast cancer is usually considered in the differential diagnosis of metastatic carcinoma in the female patient, even for those without a history of breast cancer, as some breast cancers are first diagnosed as metastases. Immunohistochemical analysis for breast cancer markers is the most common way to determine breast cancer origin besides clinical history and histology. In this review, we (1) summarize the commonly used and the newly identified breast cancer markers, including GCDFP-15, mammaglobin, GATA3, SOX10, and TRPS1; (2) point out the strengths and weaknesses of using these markers for breast cancers with luminal/epithelial or basal/myoepithelial differentiation; and (3) recommend diagnostic panels to differentiate breast carcinoma from carcinoma with similar morphology of other origins.
摘要：
由于女性乳腺癌患病率高,在女性患者的转移癌的鉴别诊断中通常考虑原发性乳腺癌的转移，即使对于那些没有乳腺癌病史的人来说，因为一些乳腺癌首先被诊断为转移。乳腺癌标志物的免疫组织化学分析是除临床病史和组织学外确定乳腺癌起源的最常见方法。在这次审查中,我们(1)总结了常用的和新发现的乳腺癌标志物，包括GCDFP-15，乳腺球蛋白，GATA3，SOX10和TRPS1；（2）指出将这些标记物用于具有腔/上皮或基底/肌上皮分化的乳腺癌的优缺点；（3）推荐诊断小组以区分乳腺癌和其他起源的形态相似的癌。
