PDF(Pubmed)
Abstract：
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and lethal lung disease characterized by progressive dyspnea and irreversible loss of lung function. Pirfenidone is a novel anti-fibrotic and anti-inflammatory drug, which reduces deterioration in the lung function and prolongs progression-free survival in patients with IPF. However, it has adverse effects including gastrointestinal symptoms, hepatic dysfunction or skin photosensitivity, and rash. Lichenoid drug eruption (LDE) refers to lichen planus-like drug eruption usually presenting symmetric eczematous plaques with a purple hue. To date, numerous cases of LDE due to various drugs and pirfenidone-associated photosensitivity have been reported. However, a case of pirfenidone-induced LDE has been very rarely reported to our knowledge. Herein, is a case of pirfenidone-induced LDE so that clinicians can be aware of the possibility of LDE when using pirfenidone.
摘要：
特发性肺纤维化(IPF)是一种慢性,进步,以进行性呼吸困难和不可逆的肺功能丧失为特征的致死性肺疾病。吡非尼酮是一种新型的抗纤维化和抗炎药，减少IPF患者的肺功能恶化并延长无进展生存期。然而,它有副作用，包括胃肠道症状，肝功能障碍或皮肤光敏性，和皮疹。苔藓样药疹（LDE）是指扁平苔藓样药疹，通常表现为紫色的对称湿疹斑块。迄今为止,已经报道了许多由于各种药物和吡非尼酮相关的光敏性引起的LDE病例。然而,据我们所知，吡非尼酮诱导的LDE病例很少报道。在这里，是吡非尼酮诱导的LDE的病例，因此临床医生在使用吡非尼酮时可以意识到LDE的可能性。
