PDF(Pubmed)
Abstract：
UNASSIGNED: The aim of this systematic review and meta-analysis was to investigate the association between obstructive sleep apnea (OSA) and erythrocytosis.
UNASSIGNED: The PubMed, Web of Science, and Cochrane Library databases were searched for articles examining hematocrit values in patients with OSA and control individuals published till September 1, 2021. The pooled standardized mean difference (SMD) with 95% confidence interval (CI) was calculated, and subgroup analyses were performed.
UNASSIGNED: Eleven eligible studies with a total of 4608 patients with OSA were included in this meta-analysis. Pooled outcomes revealed that hematocrit values were significantly higher in patients with OSA than in controls (SMD, 0.19; 95% CI, 0.08-0.29; p < .01). When studies were stratified by disease severity, the significant differences in hematocrit values between patients and controls were only observed in the severe OSA group (SMD, 0.34; 95% CI, 0.08-0.59; p < .01), but not in the mild and moderate OSA groups. In subgroup analyses according to sex and publication year, significant differences in hematocrit values between patients and controls remained stable in studies with only female patients (SMD, 0.25; 95% CI, 0.12-0.38; p < .01) and in studies published after 2012 (SMD, 0.17; 95% CI, 0.06-0.28, p < .01).
UNASSIGNED: Our meta-analysis revealed that the hematocrit value was significantly increased in patients with OSA, particularly in severe patients, compared with that in controls. However, the elevation was modest, and the hematocrit value is expected to be within the normal range in patients with OSA. These data suggest that OSA leads to slight increases in hematocrit but does not cause clinically significant erythrocytosis.
UNASSIGNED: The PubMed, Web of Science, and Cochrane Library databases were searched for articles examining hematocrit values in patients with OSA and control individuals published till September 1, 2021. The pooled standardized mean difference (SMD) with 95% confidence interval (CI) was calculated, and subgroup analyses were performed.
UNASSIGNED: Eleven eligible studies with a total of 4608 patients with OSA were included in this meta-analysis. Pooled outcomes revealed that hematocrit values were significantly higher in patients with OSA than in controls (SMD, 0.19; 95% CI, 0.08-0.29; p < .01). When studies were stratified by disease severity, the significant differences in hematocrit values between patients and controls were only observed in the severe OSA group (SMD, 0.34; 95% CI, 0.08-0.59; p < .01), but not in the mild and moderate OSA groups. In subgroup analyses according to sex and publication year, significant differences in hematocrit values between patients and controls remained stable in studies with only female patients (SMD, 0.25; 95% CI, 0.12-0.38; p < .01) and in studies published after 2012 (SMD, 0.17; 95% CI, 0.06-0.28, p < .01).
UNASSIGNED: Our meta-analysis revealed that the hematocrit value was significantly increased in patients with OSA, particularly in severe patients, compared with that in controls. However, the elevation was modest, and the hematocrit value is expected to be within the normal range in patients with OSA. These data suggest that OSA leads to slight increases in hematocrit but does not cause clinically significant erythrocytosis.
摘要：
未经证实：本系统综述和荟萃分析的目的是探讨阻塞性睡眠呼吸暂停（OSA）与红细胞增多症之间的关系。
未经授权：PubMed，WebofScience,搜索了CochraneLibrary数据库，以获取截至2021年9月1日发表的研究OSA患者和对照个体血细胞比容值的文章。计算具有95%置信区间(CI)的合并标准化平均差(SMD),进行亚组分析.
UNASSIGNED：本荟萃分析纳入了11项符合条件的研究，共4608例OSA患者。汇总结果显示，OSA患者的血细胞比容值明显高于对照组（SMD，0.19；95%CI，0.08-0.29；p<0.01）。当研究按疾病严重程度分层时，仅在重度OSA组中观察到患者和对照组之间血细胞比容值的显着差异（SMD，0.34；95%CI，0.08-0.59；p<0.01），但在轻度和中度OSA组中没有。在根据性别和出版年份进行的亚组分析中，在仅针对女性患者的研究中，患者和对照组之间的血细胞比容值存在显着差异（SMD，0.25；95%CI，0.12-0.38；p<0.01）和2012年后发表的研究（SMD，0.17；95%CI，0.06-0.28，p<0.01）。
UASSIGNED：我们的荟萃分析显示，OSA患者的血细胞比容值显著增加，特别是在重症患者中，与对照组相比。然而,海拔适中，OSA患者的血细胞比容值预计在正常范围内。这些数据表明OSA导致血细胞比容的轻微增加,但不引起临床上显著的红细胞增多症。
未经授权：PubMed，WebofScience,搜索了CochraneLibrary数据库，以获取截至2021年9月1日发表的研究OSA患者和对照个体血细胞比容值的文章。计算具有95%置信区间(CI)的合并标准化平均差(SMD),进行亚组分析.
UNASSIGNED：本荟萃分析纳入了11项符合条件的研究，共4608例OSA患者。汇总结果显示，OSA患者的血细胞比容值明显高于对照组（SMD，0.19；95%CI，0.08-0.29；p<0.01）。当研究按疾病严重程度分层时，仅在重度OSA组中观察到患者和对照组之间血细胞比容值的显着差异（SMD，0.34；95%CI，0.08-0.59；p<0.01），但在轻度和中度OSA组中没有。在根据性别和出版年份进行的亚组分析中，在仅针对女性患者的研究中，患者和对照组之间的血细胞比容值存在显着差异（SMD，0.25；95%CI，0.12-0.38；p<0.01）和2012年后发表的研究（SMD，0.17；95%CI，0.06-0.28，p<0.01）。
UASSIGNED：我们的荟萃分析显示，OSA患者的血细胞比容值显著增加，特别是在重症患者中，与对照组相比。然而,海拔适中，OSA患者的血细胞比容值预计在正常范围内。这些数据表明OSA导致血细胞比容的轻微增加,但不引起临床上显著的红细胞增多症。
