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Abstract：
Hepatitis E virus (HEV) and hepatitis C virus (HCV) are both RNA viruses with a tropism for liver parenchyma but are also capable of extrahepatic manifestations. Hepatitis E is usually a viral acute fecal-oral transmitted and self-limiting disease presenting with malaise, jaundice, nausea and vomiting. Rarely, HEV causes a chronic infection in immunocompromised persons and severe fulminant hepatitis in pregnant women. Parenteral HCV infection is typically asymptomatic for decades until chronic complications, such as cirrhosis and cancer, occur. Despite being two very different viruses in terms of phylogenetic and clinical presentations, HEV and HCV show many similarities regarding possible transmission through organ transplantation and blood transfusion, pathogenesis (production of antinuclear antibodies and cryoglobulins) and response to treatment with some direct-acting antiviral drugs. Although both HEV and HCV are well studied individually, there is a lack of knowledge about coinfection and its consequences. The aim of this review is to analyze current literature by evaluating original articles and case reports and to hypothesize some interactions that can be useful for research and clinical practice.
摘要：
戊型肝炎病毒（HEV）和丙型肝炎病毒（HCV）都是RNA病毒，对肝实质具有嗜性，但也能够表现为肝外表现。戊型肝炎通常是病毒性急性粪便-口腔传播和自限性疾病，表现为不适，黄疸,恶心和呕吐。很少,HEV在免疫功能低下的人中引起慢性感染，在孕妇中引起严重的暴发性肝炎。肠胃外HCV感染通常是无症状的几十年，直到慢性并发症，比如肝硬化和癌症，发生。尽管在系统发育和临床表现方面是两种非常不同的病毒，HEV和HCV在可能通过器官移植和输血传播方面表现出许多相似性，发病机理（抗核抗体和冷球蛋白的产生）和对某些直接作用的抗病毒药物的治疗反应。虽然HEV和HCV都有很好的单独研究，缺乏关于共感染及其后果的知识。这篇综述的目的是通过评估原始文章和病例报告来分析当前的文献，并假设一些对研究和临床实践有用的相互作用。
