LAG - 3 与稳定的 II 类 MHC 肽的结合限制了 T 细胞功能并抑制了自身免疫和抗癌免疫。
关键词: FGL1 LAG-3 MHC class II T cell autoimmunity cancer immunotherapy co-receptor immune checkpoint ligand type 1 diabetes FGL1 LAG-3 MHC class II T cell autoimmunity cancer immunotherapy co-receptor immune checkpoint ligand type 1 diabetes FGL1 LAG-3 MHC class II T cell autoimmunity cancer immunotherapy co-receptor immune checkpoint ligand type 1 diabetes
Mesh : Animals Antigens, CD / metabolism Autoimmunity Histocompatibility Antigens Class II / metabolism Ligands Mice Mice, Inbred C57BL Mice, Inbred NOD Neoplasms / immunology Peptides / metabolism T-Lymphocytes / immunology Animals Autoimmunity Histocompatibility Antigens Class II Ligands Mice Mice, Inbred C57BL Mice, Inbred NOD Neoplasms Peptides / metabolism T-Lymphocytes Animals Antigens, CD / metabolism Autoimmunity Histocompatibility Antigens Class II / metabolism Ligands Mice Mice, Inbred C57BL Mice, Inbred NOD Neoplasms / immunology Peptides / metabolism T-Lymphocytes / immunology
来 源: DOI:10.1016/j.immuni.2022.03.013