Abstract：
Purpose: Our aim was to evaluate the effects of topical antiglaucomatous medications on conjunctival thickness using anterior segment optical coherence tomography (AS-OCT). Methods: Thirty eyes of 30 patients with primary open angle glaucoma, who had never used any antiglaucomatous medications, enrolled in this prospective study. Followed by a full ophthalmologic examination, the conjunctival thickness was measured before treatment and at 1, 3, and 6-month post-treatment by AS-OCT. Measurements were taken from the superior bulbar conjunctiva, 3-4 mm from the limbus. Results: The mean age of patients was 67.7 ± 8.6; fourteen cases (46.7%) were given latanoprost, 2 cases (6.7%) brinzolamide+timolol, 2 cases (6.7%) betaxolol, 4 cases (13.3%) travoprost, and 8 cases (26.7%) brimonidine. The mean baseline conjunctival thickness was 222.9 ± 38 μm, while the mean conjunctival thickness was 212.8 ± 36.0 μm in the first month, 198.2 ± 35.8 μm in the third month, and 187.5 ± 40.2 μm in the sixth month. Decrease in conjunctival thickness at each examination was statistically significantly compared to baseline. (P < 0.05) Decrease in conjunctival thickness in Latanoprost subgroup was statistically significant, whereas the decreases in other active ingredients were not. Conclusion: Topical antiglaucomatous medications especially prostaglandin analogs may affect conjunctival thickness even during the first few months. This thinning effect may be crucial for the conjunctiva, as the basis of the possible filtration surgery.
摘要：
目的：我们的目的是使用眼前节光学相干断层扫描（AS-OCT）评估局部抗青光眼药物对结膜厚度的影响。方法:30例原发性开角型青光眼患者30只眼,从未使用过任何抗青光眼药物的人，参加了这项前瞻性研究。接下来是全面的眼科检查，在治疗前和治疗后1,3和6个月时,通过AS-OCT测量结膜厚度.测量来自上球结膜，距离角膜缘3-4毫米。结果：患者平均年龄为67.7±8.6；14例（46.7％）给予拉坦前列素，2例（6.7%）布林佐胺+噻吗洛尔，2例（6.7%）倍他洛尔，4例（13.3%）曲伏前列素，溴莫尼定8例(26.7%)。平均基线结膜厚度为222.9±38μm，而第一个月的平均结膜厚度为212.8±36.0μm，第三个月198.2±35.8μm，第六个月为187.5±40.2μm。与基线相比，每次检查时结膜厚度的减少具有统计学意义。(P<0.05)拉坦前列素亚组结膜厚度下降有统计学意义,而其他活性成分的减少则没有。结论：即使在最初的几个月中，局部抗青光眼药物尤其是前列腺素类似物也可能影响结膜厚度。这种变薄的效果可能对结膜至关重要，作为可能的过滤手术的基础。
