Abstract：
Toxoplasma gondii is an obligate intracellular parasite that causes toxoplasmosis. It has been shown that the severity of symptoms depends on the functioning of the host immune system. Although T. gondii infection typically does not lead to severe disease in healthy people and after infection, it induces a stable immunity, but it can contribute to severe and even lethal Toxoplasmosis in immunocompromised individuals (AIDS, bone marrow transplant and neoplasia). The antigens that have been proposed to be used in vaccine candidate in various studies include surface antigens and secretory excretions that have been synthesized and evaluated in different studies. In some studies, secretory antigens play an important role in stimulating the host immune response. Various antigens such as SAG, GRA, ROP, ROM, and MAG have been from different strains of T. gondii have been synthesized and their protective effects have been evaluated in animal models in different vaccine platforms including recombinant antigens, nanoparticles, and DNA vaccine. Four bibliographic databases including Science Direct, PubMed Central (PMC), Scopus, and Google Scholar were searched for articles published up to 2020.The current review article focuses on recent studies on the use and usefulness of recombinant antigens, nanoparticles, and DNA vaccines.
摘要：
弓形虫是一种引起弓形虫病的专性细胞内寄生虫。已经表明，症状的严重程度取决于宿主免疫系统的功能。虽然弓形虫感染通常不会导致健康人群和感染后的严重疾病，它诱导稳定的免疫力，但它可能导致免疫受损个体的严重甚至致命的弓形虫病(艾滋病，骨髓移植和瘤形成)。已提议在各种研究中用于候选疫苗的抗原包括已在不同研究中合成和评估的表面抗原和分泌排泄物。在一些研究中,分泌性抗原在刺激宿主免疫应答中起重要作用。各种抗原，如SAG，GRA,拖放,ROM,和MAG已经从不同菌株的弓形虫已经合成，其保护作用已经在动物模型中在不同的疫苗平台，包括重组抗原，纳米粒子，DNA疫苗四个书目数据库，包括ScienceDirect，PubMedCentral(PMC),Scopus,谷歌学者被搜索到2020年发表的文章。当前的评论文章集中在最近关于重组抗原的使用和有用性的研究，纳米粒子，DNA疫苗。
