ALS 相关的 KIF5A 突变消除了导致毒性功能获得的自身抑制。
关键词: ALS CP: Neuroscience KIF5A amyotrophic lateral sclerosis autoinhibition axonal transport kinesin neurodegenerative disease neuronal survival
Mesh : Amyotrophic Lateral Sclerosis / genetics Axonal Transport / genetics Gain of Function Mutation Humans Kinesins / genetics Mutation / genetics
来 源:
DOI:10.1016/j.celrep.2022.110598
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