Abstract：
Schisandrin A (SA) is a bioactive lignan isolated from the traditional Chinese medicine Fructus schisandrae chinensis. In recent years, it has attracted extensive attention because of its multiple pharmacological activities. This review is the first to provide an overview of SA-related pharmacological effects and pharmacokinetic characteristics. The results showed that SA had many pharmacological effects, such as antiinflammation, anticancer, hepatoprotection, antioxidation, neuroprotection, antidiabetes mellitus, and musculoskeletal protection. Among them, NF-κB, Nrf2, MAPK, NLRP3, PI3K/AKT, Wnt, miRNA, P-gp, CYP450, PXR, and other signal transduction pathways are involved. Pharmacokinetic studies showed that SA had good pharmacokinetic characteristics, but these were affected by other factors, such as drugs or hepatic fibrosis. Thus, SA has a variety of pharmacological effects and good pharmacokinetic characteristics, which is worthy of further research and development in the future.
摘要：
五味子A（SA）是从中药五味子中分离出的一种生物活性木脂素。近年来,因其具有多种药理活性而受到广泛关注。本综述首次对SA相关药理作用和药代动力学特征进行综述。结果表明,SA具有多种药理作用,比如抗炎，抗癌，肝脏保护,抗氧化，神经保护,抗糖尿病，和肌肉骨骼保护。其中,NF-κB,Nrf2,MAPK,NLRP3,PI3K/AKT,Wnt,miRNA,P-GP,CYP450,PXR,和其他信号转导途径也参与其中。药代动力学研究表明，SA具有良好的药代动力学特征，但是这些受到其他因素的影响，如药物或肝纤维化。因此，SA具有多种药理作用和良好的药代动力学特征,未来值得进一步研究和发展。
