Abstract：
Trichosporon spp. are a constituent of the normal flora of humans that can cause both superficial and invasive infections, mainly in immunocompromised and immunocompetent hosts, respectively. Herein, we a report of Trichosporon asahii causing subcutaneous fungal infection (SFI) in an immunocompetent patient after carpal tunnel surgery. Although susceptible to fluconazole, the treatment of SFI failed even using high doses of this azole. The skin lesion improved following the administration of voriconazole. We conducted a literature minireview searching reports on SFI in immunocompetent patients to check for epidemiological, diagnostic, therapeutic, and outcome characteristics. A total of 32 cases were reported. Despite being uncommon, the clinical suspicion and early diagnosis of SFI in immunocompetent patients undergoing previous surgery are important. Our study indicated that the azoles are the most active antifungal agents against Trichosporon spp., except for fluconazole, and voriconazole can be considered the first therapeutic option.
摘要：
Trichosporonspp.是人类正常菌群的组成部分，可以引起浅表和侵入性感染，主要在免疫功能低下和免疫能力强的宿主中，分别。在这里，我们报告了在腕管手术后免疫功能正常的患者中引起皮下真菌感染（SFI）。虽然对氟康唑敏感，即使使用高剂量的这种唑，SFI的治疗也失败。施用伏立康唑后皮肤损伤改善。我们进行了文献综述，在有免疫能力的患者中搜索SFI的报告，以检查流行病学，诊断,治疗性的,和结果特征。共报告32例。尽管不常见，在接受过手术的免疫功能正常的患者中,临床怀疑和早期诊断SFI非常重要.我们的研究表明，唑类药物是针对曲孢菌属的最有效的抗真菌药。,除了氟康唑,伏立康唑可以被认为是第一治疗选择。
