关键词: ACE2, Angiotensin-converting enzyme 2 CAMKII, calmodulin-dependent protein kinase II CMR, Cardiac magnetic resonance imaging COVID-19 COVID-19, Coronavirus disease 2019 CVD, Cardiovascular disease Cardiovascular diseases DAMPs, damage-associated molecular patterns IL, interleukin Myocardial infarction NOAC, novel oral anticoagulation PACS, Post-Acute COVID-19 syndrome Post covid sequelae RAAS, Renin-Angiotensin Aldosterone System dysregulation SARS-CoV 2, severe acute respiratory syndrome coronavirus 2 TMPRS2, transmembrane protease serine 2 TNF-Alpha, Tumor necrosis factor-alpha TTE, transthoracic echocardiogram UFH, Unfractionated heparin VTE, venous thromboembolism WHO, World health organization ACE2, Angiotensin-converting enzyme 2 CAMKII, calmodulin-dependent protein kinase II CMR, Cardiac magnetic resonance imaging COVID-19 COVID-19, Coronavirus disease 2019 CVD, Cardiovascular disease Cardiovascular diseases DAMPs, damage-associated molecular patterns IL, interleukin Myocardial infarction NOAC, novel oral anticoagulation PACS, Post-Acute COVID-19 syndrome Post covid sequelae RAAS, Renin-Angiotensin Aldosterone System dysregulation SARS-CoV 2, severe acute respiratory syndrome coronavirus 2 TMPRS2, transmembrane protease serine 2 TNF-Alpha, Tumor necrosis factor-alpha TTE, transthoracic echocardiogram UFH, Unfractionated heparin VTE, venous thromboembolism WHO, World health organization

来  源:   DOI:10.1016/j.ijcha.2022.101012   PDF(Pubmed)

Abstract:
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV 2) or coronavirus disease 2019 (COVID-19) initially surfaced in December 2019 from Wuhan, China, sweeping the world with various strains, forcing the WHO to declare a pandemic epidemic in March 2020. Furthermore, COVID-19 manifests with a wide array of presentations from fever and fatigue to severe respiratory and cardiovascular complications. Post-COVID-19 syndrome is poorly understood affecting COVID-19 survivors at all levels of disease severity. The disease is most associated with post-discharge dyspnea and fatigue. However, other persistent symptoms as chest pains, palpitations, smell, and taste dysfunctions. Patients with high concentrations of CRP and creatinine in the acute phase of Covid-19 are more prone to cardiac sequelae. Therefore, high levels of cardiac-sensitive troponin and hypokalaemia can also be used for risk stratification. Furthermore, Cardiac damage can manifest as myocarditis, pericarditis, rhythm abnormalities. The use of different diagnostic modalities like electrocardiogram (ECG), echocardiogram, and cardiac magnetic resonance imaging (MRI)(CMR) to evaluate the myocardial damage were studied. However, Cardiovascular complications are a common manifestation of PASC, classification of severity of cardiac symptoms and the emergence of CMR as a diagnostic tool needs more evidence.
摘要:
严重急性呼吸道综合症冠状病毒2(SARS-CoV2)或冠状病毒病2019(COVID-19)于2019年12月从武汉首次浮出水面,中国,用各种菌株席卷世界,迫使世卫组织在2020年3月宣布大流行。此外,COVID-19表现出广泛的表现,从发烧和疲劳到严重的呼吸道和心血管并发症。对COVID-19后综合征在所有疾病严重程度上影响COVID-19幸存者的了解很少。该疾病与出院后呼吸困难和疲劳最相关。然而,其他持续性症状如胸痛,心悸,气味,和味觉障碍。Covid-19急性期CRP和肌酐浓度高的患者更容易出现心脏后遗症。因此,高水平的心脏敏感性肌钙蛋白和低钾血症也可用于危险分层。此外,心脏损害可以表现为心肌炎,心包炎,节律异常.使用不同的诊断方式,如心电图(ECG),超声心动图,研究了心脏磁共振成像(MRI)评估心肌损伤的方法。然而,心血管并发症是PASC的常见表现,心脏症状严重程度的分类和CMR作为诊断工具的出现需要更多的证据.
公众号