Abstract：
Osteosarcoma (OS) is one of the most common malignant tumors in adolescents. Due to local invasion, distant metastasis and drug resistance, the clinical treatment efficacy and prognosis of OS have remained almost unchanged for decades. Epigallocatechin-3-gallate (EGCG) is a unique catechin from tea leaves, and some studies have confirmed its antitumour effects on various tumors. Here, cellular experiments showed that EGCG significantly promoted OS cell apoptosis and inhibited proliferation, migration and invasion, and cell and animal experiments demonstrated that the Wnt/β-catenin pathway played an indispensable role in the antitumour effects of EGCG. Moreover, EGCG inhibited the growth of OS cells in vitro while suppressing tumor cell damage to the bone in situ and distant lung metastasis. The results indicate that the antitumour effect of EGCG on human OS may be mediated by regulating the Wnt/β-catenin pathway and that EGCG can be used alone or in combination with other regimens as a potentially effective anticancer treatment.
摘要：
骨肉瘤（OS）是青少年最常见的恶性肿瘤之一。由于当地入侵,远处转移和耐药性，几十年来，OS的临床疗效和预后几乎没有变化。表没食子儿茶素-3-没食子酸酯（EGCG）是茶叶中独特的儿茶素，一些研究证实了它对各种肿瘤的抗肿瘤作用。这里,细胞实验表明EGCG显著促进OS细胞凋亡,抑制细胞增殖,移民和入侵，细胞和动物实验表明，Wnt/β-catenin通路在EGCG的抗肿瘤作用中起着不可或缺的作用。此外，EGCG在体外抑制OS细胞的生长，同时抑制肿瘤细胞对骨的原位和远处肺转移的损伤。结果表明，EGCG对人OS的抗肿瘤作用可能是通过调节Wnt/β-连环蛋白途径介导的，并且EGCG可以单独使用或与其他方案联合使用，作为潜在有效的抗癌治疗。
