PDF(Pubmed)
Abstract：
Calcification of intracranial aneurysms is a well-known phenomenon. Whether microsurgical or endovascular techniques are used, calcifications may increase the difficulty of treatment. However, the implications of calcification on aneurysm biology and stability have received little attention. We review both investigational and clinical methods that are used to detect aneurysmal calcification. We also discuss the pathophysiology of aneurysm calcification, specifically the role that inflammation and smooth muscle cells play. We finally turn our attention to the clinical implications of aneurysm calcification including rupture risk and treatment considerations. Calcification may represent an important feature in the life cycle of an aneurysm and as imaging methods continue to improve, we may yet discover a biomarker for this process.
摘要：
颅内动脉瘤的钙化是众所周知的现象。无论是使用显微外科手术还是血管内技术，钙化可能增加治疗难度。然而,钙化对动脉瘤生物学和稳定性的影响很少受到关注.我们回顾了用于检测动脉瘤钙化的研究和临床方法。我们还讨论了动脉瘤钙化的病理生理学，特别是炎症和平滑肌细胞的作用。最后，我们将注意力转向动脉瘤钙化的临床意义，包括破裂风险和治疗注意事项。钙化可能是动脉瘤生命周期中的一个重要特征，并且随着成像方法的不断改进，我们可能会发现这个过程的生物标志物。
