PDF(Pubmed)
Abstract：
Vanadium is a ubiquitous environmental contaminant although there are limited data to assess potential adverse human health impact following oral exposure. In support of studies investigating the subchronic toxicity of vanadyl sulfate (V4+) and sodium metavanadate (V5+) following perinatal exposure via drinking water in male and female rats, we have determined the internal exposure and urinary excretion of total vanadium at the end of study. Water consumption decreased with increasing exposure concentration following exposure to both compounds. Plasma and urine vanadium concentration normalized to total vanadium consumed per day increased with the exposure concentration of vanadyl sulfate and sodium metavanadate suggesting absorption increased as the exposure concentration increased. Additionally, females had higher concentrations than males (in plasma only for vanadyl sulfate exposure). Animals exposed to sodium metavanadate had up to 3-fold higher vanadium concentration in plasma and urine compared to vanadyl sulfate exposed animals, when normalized to total vanadium consumed per day, demonstrating differential absorption, distribution, metabolism, and excretion properties between V5+ and V4+ compounds. These data will aid in the interpretation of animal toxicity data of V4+ and V5+ compounds and determine the relevance of animal toxicity findings to human exposures.
摘要：
钒是一种普遍存在的环境污染物，尽管评估口腔暴露后对人类健康的潜在不利影响的数据有限。为了支持研究在雄性和雌性大鼠中通过饮用水围产期暴露后硫酸氧钒（V4）和偏钒酸钠（V5）的亚慢性毒性，在研究结束时，我们已经确定了总钒的内部暴露和尿排泄。暴露于两种化合物后，用水量随暴露浓度的增加而减少。随着硫酸氧钒和偏钒酸钠的暴露浓度的增加，相对于每天消耗的总钒归一化的血浆和尿液钒浓度增加，表明吸收随着暴露浓度的增加而增加。此外,女性的浓度高于男性（仅在血浆中暴露于硫酸氧钒）。与暴露于硫酸氧钒的动物相比，暴露于偏钒酸钠的动物血浆和尿液中的钒浓度高达3倍。当归一化为每天消耗的总钒时，表现出不同的吸收，分布，新陈代谢，和V5+和V4+化合物之间的排泄特性。这些数据将有助于解释V4+和V5+化合物的动物毒性数据，并确定动物毒性发现与人类暴露的相关性。
