PDF(Pubmed)
Abstract：
Environmental exposures to agrochemicals and nutritional factors may be associated with Parkinson\'s Disease (PD). None of the studies to date has examined the combined effects of diet and agricultural chemical exposure together. To address these research gaps, we aimed to assess the association of nutritional factors and agrochemical exposure with the risk of PD. A hospital-based case-control study was conducted. Multivariable logistic regressions were used to estimate the association of nutritional and agrochemical exposures with PD, adjusting for gender, age, socio-economic status, head injury, family history, smoking, metals exposure, and α-synuclein gene polymorphism. Weighted Quantile Sum (WQS) regression was applied to examine the effect of dietary components as a mixture. We recruited 347 cases and 389 controls. Parent history of PD (OR = 4.15, 95%CI: 2.10, 8.20), metals exposure (OR = 2.50, 95%CI: 1.61-3.89), SNCA rs356219 polymorphism (OR = 1.39, 95%CI: 1.04-1.87 for TC vs. TT; OR = 2.17, 95%CI: 1.43-3.28 for CC vs. TT), agrochemical exposures (OR = 2.11, 95%CI: 1.41-3.16), and being born in the Brescia province (OR = 1.83, 95%CI: 1.17-2.90) were significantly associated with PD. Conversely, fish intake and coffee consumption had a protective effect. The study confirmed the role of environmental exposures in the genesis of PD. Fish intake and coffee consumption are protective factors even when agricultural chemical exposures exist. Genetic factors and metals exposure were confirmed as risk factors for PD.
摘要：
环境暴露于农用化学品和营养因素可能与帕金森病（PD）有关。迄今为止，没有一项研究一起检查了饮食和农业化学暴露的综合影响。为了解决这些研究空白，我们旨在评估营养因素和农用化学品暴露与PD风险的关系.进行了以医院为基础的病例对照研究。多变量逻辑回归用于估计营养和农用化学品暴露与PD的关联。调整性别，年龄,社会经济地位,头部受伤,家族史,吸烟,金属暴露，和α-突触核蛋白基因多态性。应用加权分位数和(WQS)回归来检查膳食组分作为混合物的效果。我们招募了347例病例和389例对照。父母PD病史（OR=4.15，95CI：2.10，8.20），金属暴露(OR=2.50，95CI：1.61-3.89)，SNCArs356219多态性（TC与TC的OR=1.39，95CI：1.04-1.87TT；OR=2.17，95CI：CCvs.1.43-3.28TT),农用化学品暴露（OR=2.11，95CI：1.41-3.16），出生在布雷西亚省（OR=1.83，95CI：1.17-2.90）与PD显着相关。相反，鱼的摄入量和咖啡的消费有保护作用。该研究证实了环境暴露在PD发生中的作用。即使存在农业化学暴露，鱼的摄入量和咖啡的摄入量也是保护因素。遗传因素和金属暴露被证实是PD的危险因素。
