PDF(Pubmed)
Abstract：
Plant-derived products and their extracted compounds have been used in folk medicine since early times. Zimbro or common juniper (Juniperus communis) is traditionally used to treat renal suppression, acute and chronic cystitis, bladder catarrh, albuminuria, leucorrhea, and amenorrhea. These uses are mainly attributed to its bioactive composition, which is very rich in phenolics, terpenoids, organic acids, alkaloids, and volatile compounds. In the last few years, several studies have analyzed the huge potential of this evergreen shrub, describing a wide range of activities with relevance in different biomedical discipline areas, namely antimicrobial potential against human pathogens and foodborne microorganisms, notorious antioxidant and anti-inflammatory activities, antidiabetic, antihypercholesterolemic and antihyperlipidemic effects, and neuroprotective action, as well as antiproliferative ability against cancer cells and the ability to activate inductive hepato-, renal- and gastroprotective mechanisms. Owing to these promising activities, extracts and bioactive compounds of juniper could be useful for the development of new pharmacological applications in the treatment of several acute and chronic human diseases.
摘要：
自早期以来，植物衍生产品及其提取的化合物已用于民间医学。Zimbro或普通杜松（Juniperuscommunis）传统上用于治疗肾脏抑制，急性和慢性膀胱炎，膀胱粘膜炎,白蛋白尿,白带,和闭经.这些用途主要归因于其生物活性成分，富含酚类物质，萜类化合物,有机酸,生物碱，和挥发性化合物。在过去的几年里，几项研究分析了这种常绿灌木的巨大潜力，描述了与不同生物医学学科领域相关的广泛活动，即针对人类病原体和食源性微生物的抗菌潜力，臭名昭著的抗氧化和抗炎活性，抗糖尿病药,抗高胆固醇血症和抗高脂血症作用，和神经保护作用，以及对癌细胞的抗增殖能力和激活诱导肝细胞的能力，肾和胃保护机制。由于这些有希望的活动，杜松的提取物和生物活性化合物可用于开发治疗多种急性和慢性人类疾病的新药理应用。
