Abstract：
Parkinson\'s disease (PD)-a neurodegenerative disorder (NDD) characterized by progressive destruction of dopaminergic neurons within the substantia nigra of the brain-is associated with the formation of Lewy bodies containing mainly α-synuclein. HDL-related proteins such as paraoxonase 1 and apolipoproteins A1, E, D, and J are implicated in NDDs, including PD. Apolipoprotein J (ApoJ, clusterin) is a ubiquitous, multifunctional protein; besides its engagement in lipid transport, it modulates a variety of other processes such as immune system functionality and cellular death signaling. Furthermore, being an extracellular chaperone, ApoJ interacts with proteins associated with NDD pathogenesis (amyloid β, tau, and α-synuclein), thus modulating their properties. In this review, the association of clusterin with PD is delineated, with respect to its putative involvement in the pathological mechanism and its application in PD prognosis/diagnosis.
摘要：
帕金森病（PD）-一种神经退行性疾病（NDD），其特征是大脑黑质内多巴胺能神经元的进行性破坏-与主要含有α-突触核蛋白的路易体的形成有关。HDL相关蛋白，如对氧磷酶1和载脂蛋白A1，E，D,J与NDD有关，包括PD.载脂蛋白J（ApoJ，clusterin)是一种无处不在的，多功能蛋白质；除了参与脂质运输外，它调节各种其他过程，如免疫系统功能和细胞死亡信号。此外，作为细胞外伴侣，ApoJ与NDD发病机制相关的蛋白质相互作用(淀粉样β，tau,和α-突触核蛋白)，从而调节它们的属性。在这次审查中,划定了簇蛋白与PD的关联，关于其在病理机制中的推定参与及其在PD预后/诊断中的应用。
