Abstract：
The temporal relationship between length (linear) and weight (ponderal) growth in early life is important to support optimal nutrition program design. Studies based on measures of attained size have established that wasting often precedes stunting, but such studies do not capture responsiveness of growth to previous compared with current conditions. As a result, the temporality of linear and ponderal growth relationships remain unclear.
We used growth velocity indicators to assess the temporal bidirectional relationships between linear and ponderal growth in children.
Using monthly anthropometric measurements from 5039 Burkinabè children enrolled at 6 months of age and followed until 28 months from August 2014 to December 2016, we employed multilevel mixed-effects models to investigate concurrent and lagged associations between linear and ponderal growth velocity, controlling for time trends, seasonality, and morbidity.
Faster ponderal growth is associated with faster concurrent and subsequent linear growth (0.21-0.72 increase in length velocity z-score per unit increase in weight velocity z-score), while faster linear growth is associated with slower future weight gain (0.009-0.02 decrease in weight velocity z-score per unit increase in length velocity z-score), especially among children 9-14 months. Ponderal growth slows around the same time as peaks in morbidity, followed roughly a month later by slower linear growth.
Use of velocity measures to assess temporal dependencies between linear and ponderal growth demonstrate that the same growth-limiting conditions likely affect both length and weight velocity, that slow ponderal growth likely limits subsequent linear growth, and that linear growth spurts may not be accompanied by sufficient increases in dietary intake to avoid slowdowns in weight gain.
We used growth velocity indicators to assess the temporal bidirectional relationships between linear and ponderal growth in children.
Using monthly anthropometric measurements from 5039 Burkinabè children enrolled at 6 months of age and followed until 28 months from August 2014 to December 2016, we employed multilevel mixed-effects models to investigate concurrent and lagged associations between linear and ponderal growth velocity, controlling for time trends, seasonality, and morbidity.
Faster ponderal growth is associated with faster concurrent and subsequent linear growth (0.21-0.72 increase in length velocity z-score per unit increase in weight velocity z-score), while faster linear growth is associated with slower future weight gain (0.009-0.02 decrease in weight velocity z-score per unit increase in length velocity z-score), especially among children 9-14 months. Ponderal growth slows around the same time as peaks in morbidity, followed roughly a month later by slower linear growth.
Use of velocity measures to assess temporal dependencies between linear and ponderal growth demonstrate that the same growth-limiting conditions likely affect both length and weight velocity, that slow ponderal growth likely limits subsequent linear growth, and that linear growth spurts may not be accompanied by sufficient increases in dietary intake to avoid slowdowns in weight gain.
摘要：
生命早期的长度（线性）和重量（体重）增长之间的时间关系对于支持最佳营养程序设计很重要。基于所达到的大小度量的研究已经确定，消瘦通常先于发育迟缓，但与当前条件相比，此类研究无法捕获生长对以前的反应性。因此,线性和成体生长关系的时间性仍不清楚。
我们使用生长速度指标来评估儿童线性和体重生长之间的时间双向关系。
使用从2014年8月至2016年12月在6月龄注册并随访至28个月的5039名布基纳法索儿童的每月人体测量，我们采用多水平混合效应模型来研究线性和体重生长速度之间的并发和滞后关联。控制时间趋势，季节性,和发病率。
更快的体重增长与更快的并发和随后的线性增长有关（每单位重量速度z分数增加0.21-0.72长度速度z分数），而较快的线性增长与未来体重增长较慢有关（长度速度z分数每增加单位体重速度z分数减少0.009-0.02），尤其是9-14个月的儿童。在发病率达到峰值的同时，黄牛的生长减慢，大约一个月后，线性增长放缓。
使用速度测量来评估线性和体重生长之间的时间依赖性表明，相同的生长限制条件可能会影响长度和体重速度。缓慢的体重增长可能会限制随后的线性增长，并且线性生长突增可能不会伴随饮食摄入量的充分增加以避免体重增加的减慢。
我们使用生长速度指标来评估儿童线性和体重生长之间的时间双向关系。
使用从2014年8月至2016年12月在6月龄注册并随访至28个月的5039名布基纳法索儿童的每月人体测量，我们采用多水平混合效应模型来研究线性和体重生长速度之间的并发和滞后关联。
更快的体重增长与更快的并发和随后的线性增长有关（每单位重量速度z分数增加0.21-0.72长度速度z分数），
使用速度测量来评估线性和体重生长之间的时间依赖性表明，相同的生长限制条件可能会影响长度和体重速度。
