PDF(Pubmed)
Abstract：
BACKGROUND: Quetiapine, known as a non-classical antipsychotic drug, is frequently used for the treatment of mental diseases, such as schizophrenia, bipolar disorder, and major depressive disorder. Acute lung injury, a rarely reported side effect of quetiapine, is described in this case report.
METHODS: Due to terminal delirium, a 66-year-old man took a large dose of quetiapine and then developed severe pulmonary disease. His symptoms were not resolved after routine treatment, such as antibiotics, diuretic, and supportive therapies. Quetiapine-related acute lung injury was therefore suspected and hormonal therapy was initiated. Subsequently, his symptoms were alleviated and the radiological results improved dramatically.
CONCLUSIONS: Our findings in the present report highlight a potential adverse effect of quetiapine, drug-related acute lung injury, which deserves awareness in clinical practice.
METHODS: Due to terminal delirium, a 66-year-old man took a large dose of quetiapine and then developed severe pulmonary disease. His symptoms were not resolved after routine treatment, such as antibiotics, diuretic, and supportive therapies. Quetiapine-related acute lung injury was therefore suspected and hormonal therapy was initiated. Subsequently, his symptoms were alleviated and the radiological results improved dramatically.
CONCLUSIONS: Our findings in the present report highlight a potential adverse effect of quetiapine, drug-related acute lung injury, which deserves awareness in clinical practice.
摘要：
背景：喹硫平，被称为非经典抗精神病药物，经常用于治疗精神疾病，比如精神分裂症，双相情感障碍,和重度抑郁症.急性肺损伤,喹硫平罕见的副作用，在此案例报告中进行了描述。
方法：由于终末谵妄，一名66岁的男子服用了大剂量喹硫平，然后出现了严重的肺部疾病。常规治疗后症状没有缓解,比如抗生素，利尿剂,和支持性治疗。因此怀疑喹硫平相关急性肺损伤，并开始激素治疗。随后，他的症状得到缓解，放射学结果明显改善。
结论：我们在本报告中的发现突出了喹硫平的潜在不良反应，药物相关急性肺损伤，这是值得在临床实践中认识的。
方法：由于终末谵妄，一名66岁的男子服用了大剂量喹硫平，然后出现了严重的肺部疾病。常规治疗后症状没有缓解,比如抗生素，利尿剂,和支持性治疗。因此怀疑喹硫平相关急性肺损伤，并开始激素治疗。随后，他的症状得到缓解，放射学结果明显改善。
结论：我们在本报告中的发现突出了喹硫平的潜在不良反应，药物相关急性肺损伤，这是值得在临床实践中认识的。
