当归多糖通过肠道菌群改变肠道 Cldn5 、 Slit3 和 Rgs18 的表达来改善类风湿性关节炎。
关键词: Angelica Sinensis polysaccharide Bone modeling Gut microbiota Rheumatoid arthritis Tight junction Angelica Sinensis polysaccharide Bone modeling Gut microbiota Rheumatoid arthritis Tight junction
Mesh : Angelica sinensis / chemistry metabolism Animals Arthritis, Rheumatoid / drug therapy genetics metabolism Claudin-5 / biosynthesis genetics Gastrointestinal Microbiome Intestines / metabolism microbiology Membrane Proteins / biosynthesis genetics Polysaccharides / pharmacology RGS Proteins / biosynthesis genetics Rats Angelica sinensis / chemistry metabolism Animals Arthritis, Rheumatoid / drug therapy genetics metabolism Claudin-5 / biosynthesis genetics Gastrointestinal Microbiome Intestines / metabolism microbiology Membrane Proteins / biosynthesis genetics Polysaccharides / pharmacology RGS Proteins / biosynthesis genetics Rats
来 源: DOI:10.1016/j.ijbiomac.2022.03.090