PDF(Pubmed)
Abstract：
UNASSIGNED: Recurrent bacterial meningitis (RBM) is a rare but life-threatening disease. This study aims to analyze the clinical features, potential causes, and therapeutic outcomes of RBM in children.
UNASSIGNED: This article retrospectively reviews the clinical characteristics, etiologies, and treatments in children with RBM hospitalized in Hebei children\'s hospital from 2012 to 2020.
UNASSIGNED: A total of 10 children with RBM, five males and five females, were included in this study. The age of RBM in children spans from the neonatal stage to the childhood stage. The underlying illnesses were identified and classified as cerebrospinal fluid rhinorrhea (1 case), humoral immunodeficiency with Mondini dysplasia (1 case), common cavity deformity with cerebrospinal fluid ear leakage (1 case), Mondini malformations (2 cases), incomplete cochlear separation type I with a vestibular enlargement (2 cases), local inflammation of the sphenoid bone caused by cellulitis (1 case), congenital skull base defects (1 case), and congenital dermal sinus with intraspinal abscess (1 case). 6 patients chose targeted therapy for potential reasons.
UNASSIGNED: Congenital abnormalities or acquired injuries lead to intracranial communication with the outside world, which can quickly become a portal for bacterial invasion of the central nervous system, resulting in repeated infections.
UNASSIGNED: This article retrospectively reviews the clinical characteristics, etiologies, and treatments in children with RBM hospitalized in Hebei children\'s hospital from 2012 to 2020.
UNASSIGNED: A total of 10 children with RBM, five males and five females, were included in this study. The age of RBM in children spans from the neonatal stage to the childhood stage. The underlying illnesses were identified and classified as cerebrospinal fluid rhinorrhea (1 case), humoral immunodeficiency with Mondini dysplasia (1 case), common cavity deformity with cerebrospinal fluid ear leakage (1 case), Mondini malformations (2 cases), incomplete cochlear separation type I with a vestibular enlargement (2 cases), local inflammation of the sphenoid bone caused by cellulitis (1 case), congenital skull base defects (1 case), and congenital dermal sinus with intraspinal abscess (1 case). 6 patients chose targeted therapy for potential reasons.
UNASSIGNED: Congenital abnormalities or acquired injuries lead to intracranial communication with the outside world, which can quickly become a portal for bacterial invasion of the central nervous system, resulting in repeated infections.
摘要：
未经证实：复发性细菌性脑膜炎（RBM）是一种罕见但危及生命的疾病。本研究旨在分析其临床特征，潜在原因,和儿童RBM的治疗结果。
UASSIGNED：本文回顾性回顾了临床特征，病因，2012年至2020年河北省儿童医院住院RBM患儿的治疗情况。
未经评估：共有10名RBM儿童，五男五女,包括在这项研究中。儿童RBM的年龄从新生儿阶段到儿童期。基础疾病被确定并分类为脑脊液鼻漏（1例），体液免疫缺陷伴Mondini发育不良（1例），常见腔畸形伴脑脊液耳漏（1例），Mondini畸形（2例），I型不完全耳蜗分离伴前庭增大（2例），蜂窝织炎引起的蝶骨局部炎症（1例），先天性颅底缺损（1例），先天性真皮窦伴椎管内脓肿1例。6例患者出于潜在原因选择了靶向治疗。
UNASISIGNED：先天性异常或获得性损伤导致与外界的颅内通讯，它可以迅速成为细菌入侵中枢神经系统的门户，导致反复感染。
UASSIGNED：本文回顾性回顾了临床特征，病因，2012年至2020年河北省儿童医院住院RBM患儿的治疗情况。
未经评估：共有10名RBM儿童，五男五女,包括在这项研究中。儿童RBM的年龄从新生儿阶段到儿童期。基础疾病被确定并分类为脑脊液鼻漏（1例），体液免疫缺陷伴Mondini发育不良（1例），常见腔畸形伴脑脊液耳漏（1例），Mondini畸形（2例），I型不完全耳蜗分离伴前庭增大（2例），蜂窝织炎引起的蝶骨局部炎症（1例），先天性颅底缺损（1例），先天性真皮窦伴椎管内脓肿1例。6例患者出于潜在原因选择了靶向治疗。
UNASISIGNED：先天性异常或获得性损伤导致与外界的颅内通讯，它可以迅速成为细菌入侵中枢神经系统的门户，导致反复感染。
