PDF(Pubmed)
Abstract：
Autoimmune autonomic ganglionopathy (AAG) is a rare post-ganglionic disorder that causes a range of symptoms, often including gastrointestinal disorders. Patients may be seropositive or seronegative for antibodies against the nicotinic acetylcholine receptor. Here, we describe the case of a 56-year-old woman with a previous diagnosis of sensorimotor peripheral neuropathy who presented with severe constipation that was not responsive to laxative therapy. The evaluation showed diffuse colonic hypomotility, rectal hypersensitivity, and type IV pelvic floor dysfunction. The patient was diagnosed 10 months after the presentation as having seronegative AAG, and she responded well to treatment with intravenous methylprednisolone and apheresis.
摘要：
自身免疫性自主神经节（AAG）是一种罕见的节后疾病，可引起一系列症状，通常包括胃肠道疾病。患者可能对抗烟碱乙酰胆碱受体的抗体呈血清阳性或血清阴性。这里,我们描述了一例既往诊断为感觉运动周围神经病变的56岁女性,其表现为对通便治疗无反应的严重便秘.评估显示弥漫性结肠动力不足，直肠超敏反应，和IV型盆底功能障碍。患者在出现后10个月被诊断为血清阴性AAG，她对静脉注射甲基强的松龙和单采术的治疗反应良好。
