%0 Case Reports
%T Autoimmune Autonomic Ganglionopathy Presenting as Constipation.
%A Ahmed A
%A Lohman S
%A Suresh S
%A Naji A
%A Russell S
%A Alsheik E
%A Mullins K
%J Cureus
%V 14
%N 2
%D Feb 2022
%M 35308659
暂无%R 10.7759/cureus.22108
%X Autoimmune autonomic ganglionopathy (AAG) is a rare post-ganglionic disorder that causes a range of symptoms, often including gastrointestinal disorders. Patients may be seropositive or seronegative for antibodies against the nicotinic acetylcholine receptor. Here, we describe the case of a 56-year-old woman with a previous diagnosis of sensorimotor peripheral neuropathy who presented with severe constipation that was not responsive to laxative therapy. The evaluation showed diffuse colonic hypomotility, rectal hypersensitivity, and type IV pelvic floor dysfunction. The patient was diagnosed 10 months after the presentation as having seronegative AAG, and she responded well to treatment with intravenous methylprednisolone and apheresis.