Abstract：
Ischemic stroke (IS) caused by middle cerebral artery (MCA) disease is the most common type of IS caused by intracranial artery disease in the Chinese population. Hypertension and diabetes mellitus are the common risk factors of cerebral small vessel disease and large artery atherosclerosis (LAA). However, little is known about whether hypertension and diabetes mellitus had different correlations with the small artery occlusion (SAO) and LAA etiology of MCA disease. Therefore, our aim was to identify the predictors of the etiology of MCA disease.
We consecutively enrolled 967 patients with noncardiogenic IS in unilateral MCA territory. Vascular risk factors and the clinical-radiologic features of IS were analyzed. The etiology of IS were classified as SAO or LAA according to the Stop Stroke Study Trial of Org 10172 in Acute Stroke Treatment classification criteria. Multivariable logistic regression was used to identify the differences in the predictors between SAO and LAA etiology of MCA disease.
Multivariable logistic regression identified male and hypertension as the predictors of the SAO etiology of MCA disease, however diabetes mellitus, repeated transient ischemic attack before the stroke, gaze palsy, aphasia, headache at admission, and disability at discharge as the predictors of the LAA etiology of MCA disease.
Hypertension and diabetes mellitus are related with the different etiology of MCA disease.
We consecutively enrolled 967 patients with noncardiogenic IS in unilateral MCA territory. Vascular risk factors and the clinical-radiologic features of IS were analyzed. The etiology of IS were classified as SAO or LAA according to the Stop Stroke Study Trial of Org 10172 in Acute Stroke Treatment classification criteria. Multivariable logistic regression was used to identify the differences in the predictors between SAO and LAA etiology of MCA disease.
Multivariable logistic regression identified male and hypertension as the predictors of the SAO etiology of MCA disease, however diabetes mellitus, repeated transient ischemic attack before the stroke, gaze palsy, aphasia, headache at admission, and disability at discharge as the predictors of the LAA etiology of MCA disease.
Hypertension and diabetes mellitus are related with the different etiology of MCA disease.
摘要：
由大脑中动脉（MCA）疾病引起的缺血性中风（IS）是中国人群中由颅内动脉疾病引起的最常见的IS类型。高血压和糖尿病是脑小血管病和大动脉粥样硬化（LAA）的常见危险因素。然而,关于高血压和糖尿病是否与MCA疾病的小动脉闭塞（SAO）和LAA病因有不同的相关性知之甚少。因此,我们的目的是确定MCA疾病病因的预测因子.
我们连续纳入967例单侧MCA非心源性IS患者。分析了IS的血管危险因素和临床影像学特征。根据Org10172在急性中风治疗分类标准中的停止中风研究试验,将IS的病因分类为SAO或LAA。使用多变量逻辑回归来确定MCA疾病的SAO和LAA病因之间预测因素的差异。
多变量逻辑回归将男性和高血压确定为MCA疾病的SAO病因的预测因子，然而糖尿病，中风前反复的短暂性脑缺血发作，凝视麻痹,失语症,入院时头痛，出院时残疾是MCA疾病LAA病因的预测因子。
高血压和糖尿病与MCA疾病的不同病因有关。
我们连续纳入967例单侧MCA非心源性IS患者。分析了IS的血管危险因素和临床影像学特征。根据Org10172在急性中风治疗分类标准中的停止中风研究试验,将IS的病因分类为SAO或LAA。使用多变量逻辑回归来确定MCA疾病的SAO和LAA病因之间预测因素的差异。
多变量逻辑回归将男性和高血压确定为MCA疾病的SAO病因的预测因子，然而糖尿病，中风前反复的短暂性脑缺血发作，凝视麻痹,失语症,入院时头痛，出院时残疾是MCA疾病LAA病因的预测因子。
高血压和糖尿病与MCA疾病的不同病因有关。
