Abstract:
Nanocellulose has great potential in the biomedical field due to its biocompatibility, large specific surface area, and customizable surface chemistry. However, due to the bioinert nature and mismatch of the mechanical strength, nanocellulose itself has no cell adhesion ability and cannot directly promote cell growth and reproduction. Recently, surface functionalization of nanocellulose has been reported as an indispensable strategy for improving its bioactivities or other physic-chemical properties. In this paper, functionalization strategies of nanocellulose based on its inherent hydroxyl, aldehyde, carboxyl, and sulfate group reactions are reviewed. Biomacromolecules, such as peptides, proteins, and DNA that are commonly used in functionalization for different biomedical applications are summarized. Prospects and ongoing challenges of nanocellulose-based biomaterials application, as well as these advanced processing technologies such as additive manufacturing, nanomanufacturing, and bio-manufacturing are also discussed. This review is supposed to serve as a guideline for the development of nanocellulose-based biomaterials in biomedical applications.
摘要:
纳米纤维素由于其生物相容性在生物医学领域具有巨大的潜力,大的比表面积,和可定制的表面化学。然而,由于生物惰性性质和机械强度的不匹配,纳米纤维素本身没有细胞粘附能力,不能直接促进细胞生长和繁殖。最近,纳米纤维素的表面功能化已被报道为改善其生物活性或其他物理化学性质的不可或缺的策略。在本文中,基于其固有羟基的纳米纤维素的功能化策略,醛,羧基,和硫酸基团反应进行了综述。生物大分子,如肽,蛋白质,总结了常用于功能化的不同生物医学应用的DNA。纳米纤维素基生物材料应用的前景和持续挑战,以及这些先进的加工技术,如增材制造,纳米制造,和生物制造也进行了讨论。这篇综述被认为是纳米纤维素基生物材料在生物医学应用中的发展指南。