Abstract:
The cerebellum is ontogenetically one of the first structures to develop in the central nervous system; nevertheless, it has been only recently reconsidered for its significant neurobiological, functional, and clinical relevance in humans. Thus, it has been a relatively under-studied compared to the cerebrum. Currently, non-invasive imaging modalities can barely reach the necessary resolution to unfold its entire, convoluted surface, while only histological analyses can reveal local information at the micrometer scale. Herein, we used the BigBrain dataset to generate area and point-wise thickness measurements for all layers of the cerebellar cortex and for each lobule in particular. We found that the overall surface area of the cerebellar granular layer (including Purkinje cells) was 1,732 cm2 and the molecular layer was 1,945 cm2. The average thickness of the granular layer is 0.88 mm (± 0.83) and that of the molecular layer is 0.32 mm (± 0.08). The cerebellum (both granular and molecular layers) is thicker at the depth of the sulci and thinner at the crowns of the gyri. Globally, the granular layer is thicker in the lateral-posterior-inferior region than the medial-superior regions. The characterization of individual layers in the cerebellum achieved herein represents a stepping-stone for investigations interrelating structural and functional connectivity with cerebellar architectonics using neuroimaging, which is a matter of considerable relevance in basic and clinical neuroscience. Furthermore, these data provide templates for the construction of cerebellar topographic maps and the precise localization of structural and functional alterations in diseases affecting the cerebellum.
摘要:
小脑是中枢神经系统中最早发育的结构之一。尽管如此,直到最近才被重新考虑其重要的神经生物学,功能,和人类的临床相关性。因此,与大脑相比,它的研究相对不足。目前,非侵入性成像模式几乎无法达到必要的分辨率来展开其整体,盘旋表面,而只有组织学分析才能揭示微米尺度的局部信息。在这里,我们使用BigBrain数据集生成小脑皮层所有层的面积和逐点厚度测量值,特别是每个小叶.我们发现小脑颗粒层(包括浦肯野细胞)的总表面积为1,732cm2,分子层为1,945cm2。颗粒层的平均厚度为0.88mm(±0.83),分子层的平均厚度为0.32mm(±0.08)。小脑(颗粒层和分子层)在沟的深度处较厚,而在回的冠处较薄。全球范围内,颗粒层在外-后-下区域比内侧-上区域厚。本文实现的小脑中各个层的表征代表了使用神经影像学将结构和功能连通性与小脑结构相关联的研究的垫脚石,这在基础和临床神经科学中是一个相当重要的问题。此外,这些数据为小脑地形图的构建以及影响小脑的疾病的结构和功能改变的精确定位提供了模板。