Abstract：
Non-melanoma skin cancer (NMSC) is the most common malignancy seen in Caucasians and includes basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The incidence of NMSC is showing an increasing trend which is attributed to the increased use of sunbeds, recreational sun exposure, aging population, and partly to improved screening and reporting. Ultraviolet (UV) radiation plays the most crucial role in the pathogenesis of both BCC and SCC by inducing DNA damage and mutagenic photoproducts. Other risk factors are fair skin, old age, genetic predisposition, immunosuppression, ionizing radiation, organic chemicals, and HPV infection. The role of genomic instability, genetic mutations/aberrations, and host immunity has been fairly illustrated in several studies. This chapter aims to discuss these aspects of NMSC in detail.
摘要：
非黑色素瘤皮肤癌（NMSC）是白种人中最常见的恶性肿瘤，包括基底细胞癌（BCC）和鳞状细胞癌（SCC）。NMSC的发病率显示出增加的趋势，这归因于日光浴床的使用增加，休闲阳光照射，人口老龄化,部分是为了改善筛查和报告。紫外线（UV）辐射通过诱导DNA损伤和诱变光产物在BCC和SCC的发病机理中起着最关键的作用。其他危险因素是皮肤白皙，老年,遗传易感性,免疫抑制,电离辐射,有机化学品,和HPV感染。基因组不稳定性的作用，基因突变/畸变，和宿主免疫已经在一些研究中得到了相当的说明。本章旨在详细讨论NMSC的这些方面。
