钠通道 SCN5A 的错义变异体 E1295K 与复发性心室颤动和心肌炎症相关。
关键词: CAD, coronary artery disease CMP, cardiomyopathy DCM, dilated cardiomyopathy EMB, endomyocardial biopsy LV, left ventricle LVEF, left ventricular ejection fraction LVMi, left ventricular mass index MRI, magnetic resonance imaging PBMC, peripheral blood mononuclear cells PCR, polymerase chain reaction RT-PCR, reverse transcriptase polymerase chain reaction SCD, sudden cardiac death SCN5A, sodium voltage-gated channel alpha subunit 5 VES, ventricular extrasystole VF, ventricular fibrillation VT, ventricular tachycardia inflammation innate immune response ion channel diseases ion channel functions variant screening CAD, coronary artery disease CMP, cardiomyopathy DCM, dilated cardiomyopathy EMB, endomyocardial biopsy LV, left ventricle LVEF, left ventricular ejection fraction LVMi, left ventricular mass index MRI, magnetic resonance imaging PBMC, peripheral blood mononuclear cells PCR, polymerase chain reaction RT-PCR, reverse transcriptase polymerase chain reaction SCD, sudden cardiac death SCN5A, sodium voltage-gated channel alpha subunit 5 VES, ventricular extrasystole VF, ventricular fibrillation VT, ventricular tachycardia inflammation innate immune response ion channel diseases ion channel functions variant screening
来 源:
DOI:10.1016/j.jaccas.2022.01.016
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